ANTITUMOUR IMIDAZOTETRAZINES .5. CRYSTAL AND MOLECULAR-STRUCTURE OF 8-CARBAMOYL-3-(2-CHLOROETHYL)IMIDAZO[5,1-D]-1,2,3,5-TETRAZIN-4(3H)-ONE(MITOZOLOMIDE)

被引：12
|
作者：
LOWE, PR [1 ]
SCHWALBE, CH [1 ]
STEVENS, MFG [1 ]
机构：
[1] UNIV ASTON,DEPT PHARMACEUT SCI,BIRMINGHAM B4 7ET,W MIDLANDS,ENGLAND
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 1985年 / 03期
关键词：
D O I：
10.1039/p29850000357
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
引用
收藏
页码：357 / 361
页数：5
相关论文
共 50 条
  • [21] Synthesis and antiproliferative activity of 3-(2-chloroethyl)-5-methyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4-(3H)-one
    Maggio, Benedetta
    Raimondi, Maria Valeria
    Raffa, Demetrio
    Plescia, Fabiana
    Cascioferro, Stella
    Cancemi, Gabriella
    Tolomeo, Manlio
    Grimaudo, Stefania
    Daidone, Giuseppe
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 96 : 98 - 104
  • [22] Solvation Analysis of Halogenated 4-Oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
    Muthu, S.
    Paulraj, E. Isac
    ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (01) : 161 - 164
  • [23] Synthesis of trifluoromethyl-promoted functional pyrazolo [1,5-a]pyrimidine and pyrazolo [5,1-d] [1,2,3,5]tetrazine-4(3H)-ones
    Wu, YC
    Chen, YJ
    Li, HJ
    Zou, XM
    Hu, FZ
    Yang, HZ
    JOURNAL OF FLUORINE CHEMISTRY, 2006, 127 (03) : 409 - 416
  • [24] CRYSTAL AND MOLECULAR-STRUCTURE OF 1,2,3-BENZOTRIAZIN-4(3H)-ONE
    HJORTAS, J
    ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1973, 29 (SEP15): : 1916 - 1922
  • [25] CRYSTAL AND MOLECULAR-STRUCTURE OF 4-METHYL-2-PHENYL-(3H)-1,3,5,2-OXADIAZABOROLINE
    RAPER, ES
    ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1978, 34 (NOV): : 3281 - 3284
  • [26] Pyrido[2′,3′:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazine-4(3H)-ones, a new class of temozolomide heteroanalogues
    Diana, Patrizia
    Stagno, Antonina
    Barraja, Paola
    Montalbano, Alessandra
    Martorana, Annamaria
    Carbone, Anna
    Dattolo, Gaetano
    Cirrincione, Girolamo
    ARKIVOC, 2009, : 177 - 186
  • [27] Design and synthesis of novel sulfone-containing pyrazolo[1,5-a]-pyrimidines and pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones
    Wu, YC
    Zou, XM
    Hu, FZ
    Yang, HZ
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2005, 42 (04) : 609 - 613
  • [28] ANTITUMOR IMIDAZOTETRAZINES .10. EFFECT OF 8-CARBAMOYL-3-METHYLIMIDAZO[5,1-D]-1,2,3,5-TETRAZIN-4-(3H)-ONE (CCRG-81045, M-AND-B-39831, NSC-362856) ON DNA METHYLATION DURING INDUCTION OF HEMOGLOBIN-SYNTHESIS IN HUMAN-LEUKEMIA CELL-LINE K562
    TISDALE, MJ
    BIOCHEMICAL PHARMACOLOGY, 1986, 35 (02) : 311 - 316
  • [29] DFT study of cycloaddition reaction of isothiocyanates with diazoazoles to 4-imino-4H-pyrazolo[5,1-d] [1,2,3,5]thiatriazines
    Subbotina, Julia O.
    Sadchikova, Elena V.
    Bakulev, Vasiliy A.
    Fabian, Walter M. F.
    Herges, Rainer
    INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, 2007, 107 (13) : 2479 - 2488
  • [30] Antitumour imidazotetrazines. Synthesis and chemistry of 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide (nor-temozolomide): an intermediate for the preparation of the antitumour drug temozolomide and analogues, avoiding the use of isocyanates
    Cousin, David
    Stevens, Malcolm F. G.
    Hummersone, Marc G.
    MEDCHEMCOMM, 2012, 3 (11) : 1419 - 1422
12345