2-STAGE INVERSION-RECOVERY EXPERIMENTS FOR MEASUREMENTS OF T1

A theory for the optimal design of experiments for measuring values of T1 using a two-stage design is developed. It is shown that a useful strategy in such designs is to make a preliminary rough estimate of T1 and use the second stage to produce a refinement of the preliminary results. When the initial uncertainty interval for T1 is large, the two-stage design produces results much less sensitive to the value of the true T1 than those obtainable from a single-stage design. This leads to a significant improvement in the precision of estimates of T1, and in circumstances that depend on the value of T1 estimated in the first stage of the experiment, to a considerable saving in spectrometer time. © 1993 by Academic Press, Inc.