ENHANCEMENT OF NMDA TOXICITY AND CALCIUM RESPONSES BY CHRONIC EXPOSURE OF CULTURED CORTICAL-NEURONS TO ETHANOL

被引：0
|
作者：
AHERN, KV
LUSTIG, HS
GREENBERG, DA
机构：
[1] UNIV CALIF SAN FRANCISCO, DEPT NEUROL, SAN FRANCISCO, CA 94143 USA
[2] SAN FRANCISCO GEN HOSP, SAN FRANCISCO, CA 94110 USA
来源：
NEUROSCIENCE LETTERS | 1994年 / 165卷 / 1-2期
关键词：
CALCIUM; ETHANOL; EXCITOTOXICITY; FLUO-3; FURA-2; LACTATE DEHYDROGENASE; N-METHYL-D-ASPARTATE; PRIMARY NEURONAL CULTURE;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Exposure of rat cerebrocortical cultures to 100 mM ethanol for 3-4 days increased both the neurotoxic potency of N-methyl-D-aspartate (NMDA) and the maximal extent of NMDA-induced intracellular calcium (Ca-i(2+)) elevations. In both control and ethanol-treated cultures, NMDA toxicity correlated closely with [Ca2+](i). Enhancement of NMDA responses may reflect neuronal adaptation to chronic ethanol exposure and could contribute to the pathogenesis of alcohol-related neurologic disorders.
引用
收藏
页码：211 / 214
页数：4
相关论文
共 50 条
  • [31] Humanin Rescues Cultured Rat Cortical Neurons from NMDA-Induced Toxicity Not by NMDA Receptor
    Cui, Ai-Ling
    Li, Jian-Zhong
    Feng, Zhi-Bo
    Ma, Guo-Lin
    Gong, Liang
    Li, Chun-Ling
    Zhang, Ce
    Li, Kefeng
    SCIENTIFIC WORLD JOURNAL, 2014,
  • [32] BRIEF EXPOSURE TO ZINC IS TOXIC TO CORTICAL-NEURONS
    YOKOYAMA, M
    KOH, J
    CHOI, DW
    NEUROSCIENCE LETTERS, 1986, 71 (03) : 351 - 355
  • [33] RESPONSES OF VISUAL CORTICAL-NEURONS TO STATIONARY STIMULI
    DUYSENS, J
    ORBAN, GA
    VANDERGLAS, HW
    ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE, 1980, 88 (04): : P32 - P34
  • [34] CHRONIC CAFFEINE EXPOSURE REDUCES THE EXCITANT ACTION OF ACETYLCHOLINE ON CEREBRAL CORTICAL-NEURONS
    LIN, Y
    PHILLIS, JW
    BRAIN RESEARCH, 1990, 524 (02) : 316 - 318
  • [35] RESPONSES OF SINGLE CORTICAL-NEURONS TO NORADRENALINE AND DOPAMINE
    BEVAN, P
    BRADSHAW, CM
    PUN, RYK
    SLATER, NT
    SZABADI
    NEUROPHARMACOLOGY, 1978, 17 (08) : 611 - 617
  • [36] EXTRACELLULAR ALKALINITY EXACERBATES INJURY OF CULTURED CORTICAL-NEURONS
    GIFFARD, RG
    WEISS, JH
    CHOI, DW
    STROKE, 1992, 23 (12) : 1817 - 1821
  • [37] POTENTIATION OF GLUTAMATE CURRENTS BY VIP IN CULTURED CORTICAL-NEURONS
    SAH, DWY
    BIOPHYSICAL JOURNAL, 1988, 53 (02) : A356 - A356
  • [38] ZINC TOXICITY ON CULTURED CORTICAL-NEURONS - INVOLVEMENT OF N-METHYL-D-ASPARTATE RECEPTORS
    KOH, JY
    CHOI, DW
    NEUROSCIENCE, 1994, 60 (04) : 1049 - 1057
  • [39] LOCATION AND FUNCTION OF NICOTINIC RECEPTORS IN CULTURED CORTICAL-NEURONS
    LIPPIELLO, P
    COLLINS, AC
    GRAY, JA
    HEINEMANN, S
    SCHWARTZ, RD
    CLARKE, PBS
    LUNT, GG
    CIBA FOUNDATION SYMPOSIA, 1990, 152 : 109 - 112
  • [40] RESPIRATION IN PRIMARY CULTURED CEREBELLAR GRANULE NEURONS AND CEREBRAL CORTICAL-NEURONS
    JAMESON, N
    OLSON, J
    NGUYEN, H
    HOLTZMAN, D
    JOURNAL OF NEUROCHEMISTRY, 1984, 42 (02) : 470 - 474
12345