ENHANCEMENT OF NMDA TOXICITY AND CALCIUM RESPONSES BY CHRONIC EXPOSURE OF CULTURED CORTICAL-NEURONS TO ETHANOL

被引：0
|
作者：
AHERN, KV
LUSTIG, HS
GREENBERG, DA
机构：
[1] UNIV CALIF SAN FRANCISCO, DEPT NEUROL, SAN FRANCISCO, CA 94143 USA
[2] SAN FRANCISCO GEN HOSP, SAN FRANCISCO, CA 94110 USA
来源：
NEUROSCIENCE LETTERS | 1994年 / 165卷 / 1-2期
关键词：
CALCIUM; ETHANOL; EXCITOTOXICITY; FLUO-3; FURA-2; LACTATE DEHYDROGENASE; N-METHYL-D-ASPARTATE; PRIMARY NEURONAL CULTURE;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Exposure of rat cerebrocortical cultures to 100 mM ethanol for 3-4 days increased both the neurotoxic potency of N-methyl-D-aspartate (NMDA) and the maximal extent of NMDA-induced intracellular calcium (Ca-i(2+)) elevations. In both control and ethanol-treated cultures, NMDA toxicity correlated closely with [Ca2+](i). Enhancement of NMDA responses may reflect neuronal adaptation to chronic ethanol exposure and could contribute to the pathogenesis of alcohol-related neurologic disorders.
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页码：211 / 214
页数：4
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