ALTERATIONS OF GLIAL FIBRILLARY ACIDIC PROTEIN MESSENGER-RNA LEVEL IN THE AGING BRAIN AND IN SENILE DEMENTIA OF THE ALZHEIMER TYPE

被引：0
|
作者：
LEPRINCE, G [1 ]
DELAERE, P [1 ]
FAGES, C [1 ]
DUYCKAERTS, C [1 ]
HAUW, JJ [1 ]
TARDY, M [1 ]
机构：
[1] HOP LA PITIE SALPETRIERE,ASSOC CLAUDE BERNARD,INSERM,U360,F-75651 PARIS 13,FRANCE
来源：
NEUROSCIENCE LETTERS | 1993年 / 151卷 / 01期
关键词：
BLESSED TEST SCORE (BTS); ASTROCYTE; CLASSICAL SENILE PLAQUE; TEMPORAL NEOCORTEX; FRONTAL NEOCORTEX;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The GFAP mRNA levels were compared to the density of the senile plaques (SP) in postmortem brain samples of 8 cases, either non-demented or affected by senile dementia of the Alzheimer type. In the frontal neocortex, the GFAP mRNA level is not affected, even if SP are present. In the temporal neocortex, a positive correlation between GFAP mRNA level and SP density was highly significant. This shows that in this area, astrocytes are altered at transcriptional or post-transcriptional levels, or both. The different responses of this astrogliosis marker in each area may be related to the loss of specific neurotransmitter system.
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页码：71 / 73
页数：3
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