ALTERATIONS OF GLIAL FIBRILLARY ACIDIC PROTEIN MESSENGER-RNA LEVEL IN THE AGING BRAIN AND IN SENILE DEMENTIA OF THE ALZHEIMER TYPE

被引：0

作者：

LEPRINCE, G ^{[1
]}

DELAERE, P ^{[1
]}

FAGES, C ^{[1
]}

DUYCKAERTS, C ^{[1
]}

HAUW, JJ ^{[1
]}

TARDY, M ^{[1
]}

机构：

[1] HOP LA PITIE SALPETRIERE,ASSOC CLAUDE BERNARD,INSERM,U360,F-75651 PARIS 13,FRANCE

来源：

NEUROSCIENCE LETTERS | 1993年 / 151卷 / 01期

关键词：

BLESSED TEST SCORE (BTS); ASTROCYTE; CLASSICAL SENILE PLAQUE; TEMPORAL NEOCORTEX; FRONTAL NEOCORTEX;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The GFAP mRNA levels were compared to the density of the senile plaques (SP) in postmortem brain samples of 8 cases, either non-demented or affected by senile dementia of the Alzheimer type. In the frontal neocortex, the GFAP mRNA level is not affected, even if SP are present. In the temporal neocortex, a positive correlation between GFAP mRNA level and SP density was highly significant. This shows that in this area, astrocytes are altered at transcriptional or post-transcriptional levels, or both. The different responses of this astrogliosis marker in each area may be related to the loss of specific neurotransmitter system.

引用

页码：71 / 73

页数：3

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