MicroRNA (miRNA) Expression is Regulated by Butyrate-Induced Epigenetic Modulation of Gene Expression in Bovine Cells

被引：7
|
作者：
Li, Cong-Jun [1 ]
Li, Robert W. [1 ]
Elsasser, Theodore H. [1 ]
机构：
[1] USDA ARS, Bovine Funct Genom Lab, Anim & Nat Resources Inst, 10300 Baltimore Ave, Beltsville, MD 20705 USA
来源：
GENETICS & EPIGENETICS | 2010年 / 3卷
关键词：
bovine cells; butyrate; epigenetics; gene expression; miroRNA;
D O I：
10.4137/GEG.S6144
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We present evidence that butyrate induced histone acetylation regulates miRNA expression. MicroRNA expression microarray profiling revealed that 35 miRNA transcripts are significantly (P < 0.05) differentially expressed after cells were treated with 10 mM butyrate. Among them, 11 transcripts are differentially expressed very significantly (P < 0.01). The functional and pathways analysis using MetaCore analytical suite shows differentially expressed miRNAs targeting some very important gene networks and differentially expressed miRNAs may interfere with butyrate induced modulation of gene expression and cellular functions. The data indicates the complicated interaction between miRNA and histone acetylation forms a highly integrated regulatory mechanism.
引用
收藏
页码：23 / 32
页数：10
相关论文
共 50 条
  • [31] LeuO enhances butyrate-induced virulence expression through a positive regulatory loop in enterohaemorrhagic Escherichia coli
    Takao, Miyuki
    Yen, Hilo
    Tobe, Toru
    MOLECULAR MICROBIOLOGY, 2014, 93 (06) : 1302 - 1313
  • [32] Correlation between butyrate-induced histone hyperacetylation turn-over and c-myc expression
    Mariani, MR
    Carpaneto, EM
    Ulivi, M
    Allfrey, VG
    Boffa, LC
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2003, 86 (02): : 167 - 171
  • [33] Epigenetic modulation of glycoprotein VI gene expression by DNA methylation
    Gao, Shuibo
    Han, Yongjun
    Chen, Xiaohui
    Dai, Liping
    Gao, Haixia
    Lei, Zhen
    Wang, Xinzhou
    Wang, Zhentao
    Wu, Hong
    LIFE SCIENCES, 2020, 241
  • [34] Modulation of glutathione level during butyrate-induced differentiation in human colon derived HT-29 cells
    Benard, O
    Balasubramanian, KA
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 1997, 170 (1-2) : 109 - 114
  • [35] Modulation of HMG-N2 binding to chromatin by butyrate-induced acetylation in human colon adenocarcinoma cells
    Lührs, H
    Hock, R
    Schauber, J
    Weihrauch, M
    Harrer, M
    Melcher, R
    Scheppach, W
    Bustin, M
    Menzel, T
    INTERNATIONAL JOURNAL OF CANCER, 2002, 97 (05) : 567 - 573
  • [36] Oxygen regulated gene expression in mammalian cells
    Ratcliffe, PJ
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1997, 433 (06): : PL6 - PL6
  • [37] TRANSITIONS OF SPECIFIC CELL SUBPOPULATIONS AND MODULATION OF CELL-CYCLE REGULATED GENE-EXPRESSION DURING BUTYRATE SYNCHRONIZATION OF LIVER-DERIVED CELLS
    GUPTA, S
    HURSTON, E
    SHAFRITZ, DA
    HEPATOLOGY, 1989, 10 (04) : 622 - 622
  • [38] Modulation of glutathione level during butyrate-induced differentiation in human colon derived HT-29 cells
    Outhiriaradjou Benard
    K.A. Balasubramanian
    Molecular and Cellular Biochemistry, 1997, 170 : 109 - 114
  • [39] Butyrate metabolism in colonic epithelial cells is an important factor in butyrate regulation of gene expression
    Daly, Kristian
    Shirazi-Beechey, Soraya P.
    GASTROENTEROLOGY, 2007, 132 (04) : A341 - A341
  • [40] Epigenetic regulation on gene expression induced by physical exercise
    Ntanasis-Stathopoulos, J.
    Tzanninis, J-G.
    Philippou, A.
    Koutsilieris, M.
    JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS, 2013, 13 (02) : 133 - 146
12345