MicroRNA (miRNA) Expression is Regulated by Butyrate-Induced Epigenetic Modulation of Gene Expression in Bovine Cells

被引：7
|
作者：
Li, Cong-Jun [1 ]
Li, Robert W. [1 ]
Elsasser, Theodore H. [1 ]
机构：
[1] USDA ARS, Bovine Funct Genom Lab, Anim & Nat Resources Inst, 10300 Baltimore Ave, Beltsville, MD 20705 USA
来源：
GENETICS & EPIGENETICS | 2010年 / 3卷
关键词：
bovine cells; butyrate; epigenetics; gene expression; miroRNA;
D O I：
10.4137/GEG.S6144
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We present evidence that butyrate induced histone acetylation regulates miRNA expression. MicroRNA expression microarray profiling revealed that 35 miRNA transcripts are significantly (P < 0.05) differentially expressed after cells were treated with 10 mM butyrate. Among them, 11 transcripts are differentially expressed very significantly (P < 0.01). The functional and pathways analysis using MetaCore analytical suite shows differentially expressed miRNAs targeting some very important gene networks and differentially expressed miRNAs may interfere with butyrate induced modulation of gene expression and cellular functions. The data indicates the complicated interaction between miRNA and histone acetylation forms a highly integrated regulatory mechanism.
引用
下载
收藏
页码：23 / 32
页数：10
相关论文
共 50 条
  • [21] Transcriptome Characterization by RNA-seq Unravels the Mechanisms of Butyrate-Induced Epigenomic Regulation in Bovine Cells
    Wu, Sitao
    Li, Robert W.
    Li, Weizhong
    Li, Cong-Jun
    PLOS ONE, 2012, 7 (05):
  • [22] Oxygen-regulated gene expression in bovine blastocysts
    Harvey, AJ
    Kind, KL
    Pantaleon, M
    Armstrong, DT
    Thompson, JG
    BIOLOGY OF REPRODUCTION, 2004, 71 (04) : 1108 - 1119
  • [23] Genetic and Epigenetic Alterations Induced by Pesticide Exposure: Integrated Analysis of Gene Expression, microRNA Expression, and DNA Methylation Datasets
    Giambo, Federica
    Leone, Gian Marco
    Gattuso, Giuseppe
    Rizzo, Roberta
    Cosentino, Alessia
    Cina, Diana
    Teodoro, Michele
    Costa, Chiara
    Tsatsakis, Aristides
    Fenga, Concettina
    Falzone, Luca
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021, 18 (16)
  • [24] Diverse Epigenetic Enzymes Empower Regulated Gene Expression.
    Archer, T. K.
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2014, 55 : S27 - S27
  • [25] Expression of 5-lipoxygenase by human colorectal carcinoma Caco-2 cells during butyrate-induced cell differentiation
    Wächtershäuser, A
    Steinhilber, D
    Loitsch, SM
    Stein, J
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 268 (03) : 778 - 783
  • [26] Bcl-2 expression regulates sodium butyrate-induced apoptosis in human MCF-7 breast cancer cells
    Mandal, M
    Kumar, R
    CELL GROWTH & DIFFERENTIATION, 1996, 7 (03): : 311 - 318
  • [27] P38 MAPK signaling pathway is involved in butyrate-induced vitamin D receptor expression
    Daniel, C
    Schröder, O
    Zahn, N
    Gaschott, T
    Stein, J
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 324 (04) : 1220 - 1226
  • [28] Epigenetic modulation of AR gene expression in prostate cancer DU145 cells with the combination of sodium butyrate and 5′-Aza-2′-deoxycytidine
    Fialova, Barbora
    Luzna, Petra
    Gursky, Jan
    Langova, Katerina
    Kolar, Zdenek
    Trtkova, Katerina Smesny
    ONCOLOGY REPORTS, 2016, 36 (04) : 2365 - 2374
  • [29] Butyrate-induced apoptosis and cell cycle arrest in bovine kidney epithelial cells: Involvement of caspase and proteasome pathways
    Li, CJ
    Elsasser, TH
    JOURNAL OF ANIMAL SCIENCE, 2005, 83 (01) : 89 - 97
  • [30] MODULATION OF SPARC EXPRESSION DURING BUTYRATE-INDUCED TERMINAL DIFFERENTIATION OF CULTURED HUMAN KERATINOCYTES - REGULATION VIA A TGF-BETA-DEPENDENT PATHWAY
    FORD, R
    WANG, G
    JANNATI, P
    ADLER, D
    RACANELLI, P
    HIGGINS, PJ
    STAIANOCOICO, L
    EXPERIMENTAL CELL RESEARCH, 1993, 206 (02) : 261 - 275
12345