MicroRNA (miRNA) Expression is Regulated by Butyrate-Induced Epigenetic Modulation of Gene Expression in Bovine Cells

被引：7

作者：

Li, Cong-Jun ^{[1
]}

Li, Robert W. ^{[1
]}

Elsasser, Theodore H. ^{[1
]}

机构：

[1] USDA ARS, Bovine Funct Genom Lab, Anim & Nat Resources Inst, 10300 Baltimore Ave, Beltsville, MD 20705 USA

来源：

GENETICS & EPIGENETICS | 2010年 / 3卷

关键词：

bovine cells; butyrate; epigenetics; gene expression; miroRNA;

D O I：

10.4137/GEG.S6144

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We present evidence that butyrate induced histone acetylation regulates miRNA expression. MicroRNA expression microarray profiling revealed that 35 miRNA transcripts are significantly (P < 0.05) differentially expressed after cells were treated with 10 mM butyrate. Among them, 11 transcripts are differentially expressed very significantly (P < 0.01). The functional and pathways analysis using MetaCore analytical suite shows differentially expressed miRNAs targeting some very important gene networks and differentially expressed miRNAs may interfere with butyrate induced modulation of gene expression and cellular functions. The data indicates the complicated interaction between miRNA and histone acetylation forms a highly integrated regulatory mechanism.

引用

页码：23 / 32

页数：10

共 50 条

[1] Epigenetic modulation of gene expression in mammalian cells
Xu, D
Juliano, RL
[J]. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2005, 15 (02): : 93 - 101
[2] Butyrate-induced PPARγ expression is not associated with epithelial cell differentiation
Ulrich, S
Gaschott, T
Waechtershaeuser, A
Stein, J
[J]. GASTROENTEROLOGY, 2004, 126 (04) : A523 - A523
[3] Expression profiling analysis of sodium butyrate-induced chinese hamster ovary cells in defined medium
Melville, MW
Sinacore, M
Hann, LE
[J]. ANIMAL CELL TECHNOLOGY MEETS GENOMICS, 2005, : 79 - 82
[4] EXPRESSION OF HUMAN PLATELET-ACTIVATING-FACTOR RECEPTOR GENE IN EOL-1 CELLS FOLLOWING BUTYRATE-INDUCED DIFFERENTIATION
IZUMI, T
KISHIMOTO, S
TAKANO, T
NAKAMURA, M
MIYABE, Y
NAKATA, M
SAKANAKA, C
SHIMIZU, T
[J]. BIOCHEMICAL JOURNAL, 1995, 305 : 829 - 835
[5] The gene expression pattern induced by high plating density in cultured bovine and buffalo granulosa cells might be regulated by specific miRNA species
Yenuganti, Vengala Rao
Baddela, Vijay Simha
Baufeld, Anja
Singh, Dheer
Vanselow, Jens
[J]. JOURNAL OF REPRODUCTION AND DEVELOPMENT, 2015, 61 (02): : 154 - 160
[6] Butyrate-induced Ca2+ transients and regulation of neurotransmitter-related gene expression in PC12 cells
Zia, MT
Decastro, MH
Krishnan, K
Nankova, BB
LaGamma, EF
[J]. PEDIATRIC RESEARCH, 2003, 53 (04) : 58A - 58A
[7] GPR109A IS INVOLVED IN BUTYRATE-INDUCED HSP25 EXPRESSION IN COLONIC EPITHELIAL CELLS
Kashiwagi, Saori
Uchiyama, Kazuhiko
Ogita, Kazuyuki
Ota, Takayuki
Takayama, Shun
Yasuda, Ritsu
Yoshida, Jyuichiro
Mukai, Rieko
Nakano, Takahiro
Murakami, Takaaki
Suyama, Yosuke
Toyokawa, Yuki
Ueda, Tomohiro
Yasuda, Tomoyo
Mizushima, Katsura
Dohi, Osamu
Okayama, Tetsuya
Yoshida, Naohisa
Katada, Kazuhiro
Kamada, Kazuhiro
Ishikawa, Takeshi
Handa, Osamu
Takagi, Tomohisa
Yasuda, Hiroaki
Konishi, Hideyuki
Naito, Yuji
Itoh, Yoshito
[J]. GASTROENTEROLOGY, 2018, 154 (06) : S923 - S923
[8] Expression of 5-lipoxygenase during butyrate-induced cell differentiation of human carcinoma cells.
Waechtershaeuser, A
Loitsch, SM
Steinhilber, D
Caspary, WF
Stein, J
[J]. GASTROENTEROLOGY, 2000, 118 (04) : A555 - A555
[9] BUTYRATE SYNCHRONIZATION OF HEPATOCYTES - MODULATION OF CYCLING AND CELL-CYCLE-REGULATED GENE-EXPRESSION
GUPTA, S
ALPINI, G
VEMURU, RP
HURSTON, E
SHAFRITZ, DA
[J]. GROWTH FACTORS, 1994, 10 (03) : 171 - 180
[10] Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression
Klampfer, L
Huang, J
Sasazuki, T
Shirasawa, S
Augenlicht, L
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (35) : 36680 - 36688

← 1 2 3 4 5 →