PHOTOINDUCED DNA STRAND SCISSION BY 1,8-NAPHTHALIMIDE-DERIVED INTERCALATORS

被引：0

作者：

MEHROTRA, J

MISRA, K

MISHRA, RK

机构：

[1] CTR CELLULAR & MOLEC BIOL,HYDERABAD 500007,INDIA

[2] UNIV ALLAHABAD,DEPT CHEM,ALLAHABAD 211002,UTTAR PRADESH,INDIA

来源：

CURRENT SCIENCE | 1992年 / 62卷 / 10期

关键词：

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

DNA cleavage by non-enzymatic chemical reagents has both basic and applied value. We report here photoinduced strand scission properties of novel DNA intercalators, 4-nitro (N-hexylamine) 1,8-naphthalimide and 4-amino(N-hexylamine) 1,8-naphthalimide. The results indicate that the cleavage takes place via a free-radical mechanism and the efficiency of cleavage is unaltered over a long range of pH and ionic strength. These intercalators, therefore, provide a probe for studying DNA conformation, conformational micro-heterogeneity, DNA-ligand interactions and have potential use in genome targeting.

引用

页码：693 / 695

页数：3

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