PHOTOINDUCED DNA STRAND SCISSION BY 1,8-NAPHTHALIMIDE-DERIVED INTERCALATORS

被引：0
|
作者：
MEHROTRA, J
MISRA, K
MISHRA, RK
机构：
[1] CTR CELLULAR & MOLEC BIOL,HYDERABAD 500007,INDIA
[2] UNIV ALLAHABAD,DEPT CHEM,ALLAHABAD 211002,UTTAR PRADESH,INDIA
来源：
CURRENT SCIENCE | 1992年 / 62卷 / 10期
关键词：
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
DNA cleavage by non-enzymatic chemical reagents has both basic and applied value. We report here photoinduced strand scission properties of novel DNA intercalators, 4-nitro (N-hexylamine) 1,8-naphthalimide and 4-amino(N-hexylamine) 1,8-naphthalimide. The results indicate that the cleavage takes place via a free-radical mechanism and the efficiency of cleavage is unaltered over a long range of pH and ionic strength. These intercalators, therefore, provide a probe for studying DNA conformation, conformational micro-heterogeneity, DNA-ligand interactions and have potential use in genome targeting.
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页码：693 / 695
页数：3
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