ASYMMETRIC TRANSESTERIFICATION OF MESO-2,5-DIBROMOADIPATE AND SYNTHESIS OF OPTICALLY-ACTIVE CIS-2,5-DISUBSTITUTED PYRROLIDINES

被引：5
|
作者：
OZASA, N [1 ]
TOKIOKA, K [1 ]
YAMAMOTO, Y [1 ]
机构：
[1] KYOTO UNIV, GRAD SCH HUMAN & ENVIRONM SCI, KYOTO 60601, JAPAN
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1995年 / 59卷 / 10期
关键词：
D O I：
10.1271/bbb.59.1905
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Asymmetric trans-esterification of meso-2,5-dibromoadipate to (-)-benzyl methyl 2,5-dibromoadipate by lipase with subsequent chemical reactions afforded optically active cis-2,5-disubstituted pyrrolidines. An equivalent asymmetric transformation was performed by selectively hydrolyzing a cis-2,5-disubstituted pyrrolidine having a chiral N-substituent.
引用
收藏
页码：1905 / 1907
页数：3
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