ASYMMETRIC TRANSESTERIFICATION OF MESO-2,5-DIBROMOADIPATE AND SYNTHESIS OF OPTICALLY-ACTIVE CIS-2,5-DISUBSTITUTED PYRROLIDINES

被引：5

作者：

OZASA, N ^{[1
]}

TOKIOKA, K ^{[1
]}

YAMAMOTO, Y ^{[1
]}

机构：

[1] KYOTO UNIV, GRAD SCH HUMAN & ENVIRONM SCI, KYOTO 60601, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1995年 / 59卷 / 10期

关键词：

D O I：

10.1271/bbb.59.1905

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Asymmetric trans-esterification of meso-2,5-dibromoadipate to (-)-benzyl methyl 2,5-dibromoadipate by lipase with subsequent chemical reactions afforded optically active cis-2,5-disubstituted pyrrolidines. An equivalent asymmetric transformation was performed by selectively hydrolyzing a cis-2,5-disubstituted pyrrolidine having a chiral N-substituent.

引用

页码：1905 / 1907

页数：3

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