5-(5-BROMOTHIEN-2-YL)-2'-DEOXYURIDINE AND 5-(5-CHLOROTHIEN-2-YL)-2'-DEOXYURIDINE ARE EQUIPOTENT TO (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE IN THE INHIBITION OF HERPES-SIMPLEX VIRUS TYPE-I REPLICATION

被引：87

作者：

WIGERINCK, P ^{[1
]}

PANNECOUQUE, C ^{[1
]}

SNOECK, R ^{[1
]}

CLAES, P ^{[1
]}

DECLERCQ, E ^{[1
]}

HERDEWIJN, P ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,REGA INST MED RES,MINDERBROEDERSSTR 10,B-3000 LOUVAIN,BELGIUM

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 08期

关键词：

D O I：

10.1021/jm00112a011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2'-Deoxyuridines with a five-membered heterocyclic substituent in the 5-position were synthesized by palladium-catalyzed coupling reactions of 5-iodo-2'-deoxyuridine with the activated heteroaromatics. Further modification of the compound with the 5-thien-2-yl substituent gave 5-(5-bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothienyl-2-yl)-2'-deoxyuridine. Both compounds show potent and selective activity against herpes simplex virus type 1 and varicella-zoster virus.

引用

页码：2383 / 2389

页数：7

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