5-(THIEN-2-YL)-2'-DEOXYURIDINE - A NEW AND POTENT INHIBITOR OF HERPES-SIMPLEX VIRUS TYPE-1 REPLICATION

被引：1
|
作者：
WIGERINCK, P
VANAERSCHOT, A
DECLERCQ, E
HERDEWIJN, P
机构：
[1] Rega Institute for Medical Research, Katholieke Universiteit Leuven
来源：
NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 1-3期
关键词：
D O I：
10.1080/07328319108046537
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
5-(Thien-2-yl)-2'-deoxyuridine, synthesized by coupling of 5-iodo-2'-deoxyuridine with 2-trimethylstannylthiophene in the presence of a Pd catalyst, shows potent anti-HSV-1 activity in vitro.
引用
收藏
页码：585 / 586
页数：2
相关论文
共 50 条
  • [1] HERPES-SIMPLEX VIRUS TYPE-1 THAT EXHIBITS HERPES-SIMPLEX VIRUS TYPE-2 SENSITIVITY TO (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE
    DOCHERTY, JJ
    DOBSON, AT
    TRIMBLE, JJ
    JENNINGS, BA
    INTERVIROLOGY, 1991, 32 (05) : 308 - 315
  • [2] 5-(thien-2-yl) uracil analogs: 5-(5-methylthien-2-yl)-2'-deoxyuridine, 5-(5-thien-2-yl)-2'-deoxyuridine, and 5-(5-bromothien-2-yl)-2'-deoxyuridine
    Creuven, I
    Norberg, B
    Olivier, A
    Evrard, C
    Evrard, G
    Wigerinck, P
    Herdewijn, P
    Durant, F
    JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, 1996, 26 (11) : 777 - 789
  • [3] 5-(5-BROMOTHIEN-2-YL)-2'-DEOXYURIDINE AND 5-(5-CHLOROTHIEN-2-YL)-2'-DEOXYURIDINE ARE EQUIPOTENT TO (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE IN THE INHIBITION OF HERPES-SIMPLEX VIRUS TYPE-I REPLICATION
    WIGERINCK, P
    PANNECOUQUE, C
    SNOECK, R
    CLAES, P
    DECLERCQ, E
    HERDEWIJN, P
    JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (08) : 2383 - 2389
  • [4] DIFFERENTIATION OF HERPES-SIMPLEX VIRUS TYPE-1 AND TYPE-2 BY SENSITIVITY TO (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE
    MAYO, DR
    JOURNAL OF CLINICAL MICROBIOLOGY, 1982, 15 (04) : 733 - 736
  • [5] DIFFERENTIAL EFFECTS OF 5-METHYLMERCAPTO-2'-DEOXYURIDINE ON REPLICATION OF HERPES-SIMPLEX VIRUS TYPE-1 IN 2 CELL SYSTEMS
    HARDI, R
    HUGHES, RG
    HO, YK
    CHADHA, KC
    BARDOS, TJ
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1976, 10 (04) : 682 - 686
  • [6] MECHANISM OF ACTION OF 5-(2-CHLOROETHYL)-2'-DEOXYURIDINE, A SELECTIVE INHIBITOR OF HERPES-SIMPLEX VIRUS-REPLICATION
    DECLERCQ, E
    BERNAERTS, R
    MERTA, A
    ROSENWIRTH, B
    MOLECULAR PHARMACOLOGY, 1990, 37 (05) : 658 - 664
  • [7] INHIBITION OF HERPES-SIMPLEX VIRUS TYPE-1 AND TYPE-2 REPLICATION INVITRO BY MERCURITHIO ANALOGS OF DEOXYURIDINE
    HOLLIDAY, J
    WILLIAMS, MV
    ANTIVIRAL RESEARCH, 1991, 16 (02) : 197 - 203
  • [8] THE EFFECT OF (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE ON DNA-REPAIR AND MUTAGENESIS OF HERPES-SIMPLEX VIRUS TYPE-1
    BUBLEY, GJ
    BALZARINI, J
    CRUMPACKER, CS
    DECLERCQ, E
    SCHNIPPER, LE
    VIROLOGY, 1987, 161 (01) : 242 - 244
  • [9] EXPERIMENTAL HERPES-SIMPLEX VIRUS TYPE-1 ENCEPHALITIS - TREATMENT WITH 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE
    CLOUGH, DW
    PARKHURST, JR
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1977, 11 (02) : 307 - 311
  • [10] ANALYSIS OF THE THYMIDINE KINASE OF A HERPES-SIMPLEX VIRUS TYPE-1 ISOLATE THAT EXHIBITS RESISTANCE TO (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE
    WILBER, BAJ
    DOCHERTY, JJ
    JOURNAL OF GENERAL VIROLOGY, 1994, 75 : 1743 - 1747
12345