5-(THIEN-2-YL)-2'-DEOXYURIDINE - A NEW AND POTENT INHIBITOR OF HERPES-SIMPLEX VIRUS TYPE-1 REPLICATION

被引：1
|
作者：
WIGERINCK, P
VANAERSCHOT, A
DECLERCQ, E
HERDEWIJN, P
机构：
[1] Rega Institute for Medical Research, Katholieke Universiteit Leuven
来源：
NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 1-3期
关键词：
D O I：
10.1080/07328319108046537
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
5-(Thien-2-yl)-2'-deoxyuridine, synthesized by coupling of 5-iodo-2'-deoxyuridine with 2-trimethylstannylthiophene in the presence of a Pd catalyst, shows potent anti-HSV-1 activity in vitro.
引用
收藏
页码：585 / 586
页数：2
相关论文
共 50 条
  • [31] STUDIES ON THE MECHANISM OF ANTIVIRAL ACTION OF 5-(2-CHLOROETHYL)-2'-DEOXYURIDINE AGAINST HERPES-SIMPLEX VIRUS
    BERNAERTS, R
    STERKENS, P
    HERDEWIJN, P
    ROSENWIRTH, B
    DECLERCQ, E
    ANTIVIRAL RESEARCH, 1988, 9 (1-2) : 111 - 111
  • [32] TREATMENT OF EXPERIMENTAL HERPES-SIMPLEX VIRUS ENCEPHALITIS WITH (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE IN MICE
    DECLERCQ, E
    ZHANG, ZX
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1982, 22 (03) : 421 - 425
  • [33] PROBLEMS ASSOCIATED WITH THE USE OF (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE FOR TYPING HERPES-SIMPLEX VIRUS
    SWIERKOSZ, EM
    ARENS, MQ
    RIVETNA, KA
    JOURNAL OF CLINICAL MICROBIOLOGY, 1985, 21 (03) : 459 - 461
  • [34] STEROID-HORMONE ALTERATION OF HERPES-SIMPLEX VIRUS TYPE-1 REPLICATION
    NOTTER, MFD
    DOCHERTY, JJ
    JOURNAL OF MEDICAL VIROLOGY, 1978, 2 (03) : 247 - 252
  • [35] MODULATION OF HERPES-SIMPLEX VIRUS TYPE-1 REPLICATION BY HUMAN SALIVARY SECRETIONS
    BERGEY, EJ
    GU, M
    COLLINS, AR
    BRADWAY, SD
    LEVINE, MJ
    ORAL MICROBIOLOGY AND IMMUNOLOGY, 1993, 8 (02): : 89 - 93
  • [36] ENHANCED REPLICATION OF HERPES-SIMPLEX VIRUS TYPE-1 IN HUMAN-CELLS
    MILLER, CS
    SMITH, KO
    JOURNAL OF DENTAL RESEARCH, 1991, 70 (02) : 111 - 117
  • [37] EFFECTS OF CYTOCHALASIN-B ON HERPES-SIMPLEX VIRUS TYPE-1 REPLICATION
    DIX, RD
    COURTNEY, RJ
    VIROLOGY, 1976, 70 (01) : 127 - 135
  • [38] CYTOTOXICITY OF A REPLICATION-DEFECTIVE MUTANT OF HERPES-SIMPLEX VIRUS TYPE-1
    JOHNSON, PA
    MIYANOHARA, A
    LEVINE, F
    CAHILL, T
    FRIEDMANN, T
    JOURNAL OF VIROLOGY, 1992, 66 (05) : 2952 - 2965
  • [39] DIFFERENTIAL EFFECT OF TEMPERATURE ON REPLICATION OF HERPES-SIMPLEX VIRUS TYPE 1 AND TYPE 2
    CROUCH, NA
    RAPP, F
    VIROLOGY, 1972, 50 (03) : 939 - 941
  • [40] HERPES-SIMPLEX VIRUS TYPE-1 AND TYPE-2 COMPLETELY HELP ADENOVIRUS-ASSOCIATED VIRUS-REPLICATION
    BULLER, RML
    JANIK, JE
    SEBRING, ED
    ROSE, JA
    JOURNAL OF VIROLOGY, 1981, 40 (01) : 241 - 247
12345