A review on synthesis and biological screening of oxazepinedione derivatives

At present a number of drugs with various mechanism of action are available for the pharmacotherapy of psychopharmacological disorders. Among them, the most important are dibenzoxazepine and benzodiazepine derivatives. Important drugs contain oxazepine rings are amoxapine and loxapine which are used as typical antipsychotic agents. Oxazepines are seven membered heterocyclic compounds which contribute to various important activities. Nowadays a wide variety of Oxazepinediones derivatives are synthesized and biologically screened for anticancer, antimicrobial and enzymatic activities etc. Oxazepinediones are commonly synthesized by cycloaddition reaction with schiff base and various anhydride (phthalic anhydride/maleic anhydride/succinic anhydride) or haloacids.