THE REACTIONS OF PHOSPHONODITHIOFORMATES WITH NUCLEOPHILIC-REAGENTS

The reactions of phosphonodithioformates with trialkylphosphites, organometallics, hydrides, radicals, amines and thiols have been studied. The results obtained demonstrate that these phosphonodithioesters can be used for carbon-carbon bond formation via their reaction with organometallics (ketene dithioacetals, homologation of aldehydes) and for the preparation of substituted methylene bis-(phosphonates) via stabilised ylids. They are radical trapping agents and also precursors of a large variety of new functionalised phosphonates which may have biological activities [thiocarbamoylphosphonates, (aminomethyl)-, [tris-(alkylthiomethyl)]- and (mercaptomethyl)-phosphonate derivatives].