STUDIES ON THE ANTITUMOR 2,6-PIPERAZINEDIONES - SYNTHESIS OF 2,3-DIACETOXY-4-CARBOMETHOXY-(3',5'-DIOXO-N-4' SUBSTITUTED PIPERAZINYL METHYL) BENZENE

被引：0
|
作者：
LI, Q
SHAO, HW
JIANG, HL
XIE, YY
机构：
来源：
PHARMAZIE | 1995年 / 50卷 / 07期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The title compounds having the structure of 2,3-diacetoxy-4-carbomethoxy-(3',5'-dioxo-N-4'-substituted piperazinyl methyl) benzene were synthesized from 2-hydroxy-3-methoxybenzaldehyde in eight steps. Compound 9h showed a potent inhibitory effect against P388 leukemia cells in vitro.
引用
收藏
页码：447 / 449
页数：3
相关论文
共 50 条
  • [1] A highly stereoselective synthesis of 2-carbomethoxy-3-aryl-4-carboethoxy-5-methyl-cis-2,3-dihydrofurans
    Ding, YY
    Chen, YL
    Zhang, Y
    Yao, Y
    CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 1996, 12 (04) : 354 - 359
  • [2] A　Highly　Stereoselective　Synthesis　of　2－Carbomethoxy－3－aryl－4－carboethoxy－5－methyl－cis－2，3－dihydrofurans
    DING Wei-yu
    CHEN Ya-li
    ZHANG Yi and YAO Yuan(Department of Chemistry
    ChemicalResearchinChineseUniversities, 1996, (04) : 354 - 359
  • [3] SYNTHESIS AND 5-HT RECEPTORS BINDING-STUDIES OF SOME 3-SUBSTITUTED-2-(4-METHYL-1-PIPERAZINYL)-4-PHENYLQUINOLINES
    ANZINI, M
    CAPPELLI, A
    VOMERO, S
    CAMPIANI, G
    CAGNOTTO, A
    SKORUPSKA, M
    FARMACO, 1991, 46 (12): : 1435 - 1447
  • [4] 4-SUBSTITUTED PIPERIDINES .4. SYNTHESIS OF 4-[(2,6-DIOXO-3-PHENYL)-3-PIPERIDYL]PIPERIDINES
    HERMANS, B
    VANDAELE, P
    VANDEWES.C
    VANDEREY.C
    BOEY, J
    DOCKX, J
    JANSSEN, PAJ
    JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (04) : 797 - &
  • [5] STUDIES ON 2,3,N,N'-SUBSTITUTED 4,4'-DIAMINODIPHENYLSULFONES AS POTENTIAL ANTIMALARIAL AGENTS
    SAXENA, M
    SAXENA, AK
    RAINA, R
    CHANDRA, S
    SEN, AB
    ANAND, N
    SEYDEL, JK
    WIESE, M
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1989, 39-2 (09): : 1081 - 1084
  • [6] SYNTHESIS OF 3-SUBSTITUTED-4-METHYL-5-ACETYL-4-THIAZOLINE-2-THIONE
    DAMICO, JJ
    BOLLINGER, FG
    FREEMAN, JJ
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1986, 23 (01) : 101 - 104
  • [7] Electrochemical studies on N′-(2-hydroxybenzoyl)-3-methyl-4-(4′-substituted arylhydrazono)-2-pyrazolin-5-ones
    Satyanarayana, DN
    Ravindranath, LK
    Sankar, TR
    Venkataramana, P
    BULLETIN OF ELECTROCHEMISTRY, 2003, 19 (06): : 279 - 282
  • [8] SYNTHESIS OF N-SUBSTITUTED 3-HYDROXY-2-METHYL-4-PYRIDONES AND 3-HYDROXY-2-METHYL-4-PYRIDONIMINES
    FARBER, M
    OSIANDER, H
    SEVERIN, T
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1994, 31 (04) : 947 - 956
  • [9] ANTICANCER AGENTS .3. SYNTHESIS OF SUBSTITUTED 2-(4-METHYL-PHENYL-1-PIPERAZINYL)-PROPANES
    BANERJEE, D
    DUTTA, PK
    DUTTA, NL
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1974, 51 (02) : 348 - 350
  • [10] SYNTHESIS OF N-ISONICOTINYL-3-METHYL-4-(SUBSTITUTED HYDRAZONO)-2-PYRAZOLIN-5-ONE
    SINGH, CP
    OJHA, AC
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1980, 57 (12) : 1172 - 1173
12345