PLASMID-MEDIATED EXTENDED SPECTRUM BETA-LACTAMASES

被引：1
|
作者：
WIEDEMANN, B
机构：
[1] Pharm. Mikrobiologie der Universität Bonn, D-5300 Bonn 1
来源：
MEDECINE ET MALADIES INFECTIEUSES | 1992年 / 22卷
关键词：
EXTENDED SPECTRUM BETA-LACTAMASES; EVOLUTION OF TRANSPOSON MEDIATED BETA-LACTAMASES WITH A BROADENED SUBSTRATE PROFILE; EVOLUTION OF BACTERIAL SELECTION MECHANISMS; LEGITIMATE AND ILLEGITIMATE RECOMBINATION;
D O I：
10.1016/S0399-077X(05)80864-9
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The classical plasmid-mediated beta-lactamases can alter their specificity towards the hydrolysis of so-called beta-lactamase stable compounds, such as third-generation cephalosporins, by simple one step mutation and subsequent selection. Although currently this mechanism is rare, it causes concern in specific clinical settings and precautions have to be taken in order to prevent the spread of this particular resistance mechanism.
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页码：524 / 528
页数：5
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