VIRAL PROTEIN-KINASES AND PROTEIN PHOSPHATASES

被引：46
|
作者：
LEADER, DP
机构：
[1] Department of Biochemistry, University of Glasgow, Glasgow
来源：
PHARMACOLOGY & THERAPEUTICS | 1993年 / 59卷 / 03期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/0163-7258(93)90075-O
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Certain large DNA viruses (e.g. herpesviruses and poxviruses) encode proteins related to cellular protein-serine/threonine kinases, and Hepatitis B virus and vesicular stomatitis virus may encode structurally different protein kinases. Other viruses activate cellular protein kinases, e.g. interferon-induced eukaryotic initiation factor-2 kinase, growth factor-induced kinases and protein kinases that regulate mitosis. Protein phosphatases are encoded by vaccinia virus and bacteriophage lambda and must also play a role in viral infection-as do cellular protein phosphatases. The functions of many of these viral enzymes remain to be determined, but they represent possible new targets for anti-viral therapy.
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页码：343 / 389
页数：47
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