VIRAL PROTEIN-KINASES AND PROTEIN PHOSPHATASES

被引：46

作者：

LEADER, DP

机构：

[1] Department of Biochemistry, University of Glasgow, Glasgow

来源：

PHARMACOLOGY & THERAPEUTICS | 1993年 / 59卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0163-7258(93)90075-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Certain large DNA viruses (e.g. herpesviruses and poxviruses) encode proteins related to cellular protein-serine/threonine kinases, and Hepatitis B virus and vesicular stomatitis virus may encode structurally different protein kinases. Other viruses activate cellular protein kinases, e.g. interferon-induced eukaryotic initiation factor-2 kinase, growth factor-induced kinases and protein kinases that regulate mitosis. Protein phosphatases are encoded by vaccinia virus and bacteriophage lambda and must also play a role in viral infection-as do cellular protein phosphatases. The functions of many of these viral enzymes remain to be determined, but they represent possible new targets for anti-viral therapy.

引用

页码：343 / 389

页数：47

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