DOSE-RESPONSE RELATIONSHIPS FOR TOPICALLY APPLIED ANTIGENS

被引：20
|
作者：
EUN, HC [1 ]
MARKS, R [1 ]
机构：
[1] UNIV COLL CARDIFF,DEPT MED DERMATOL,HEATH PK,CARDIFF CF4 4XN,S GLAM,WALES
来源：
BRITISH JOURNAL OF DERMATOLOGY | 1990年 / 122卷 / 04期
关键词：
D O I：
10.1111/j.1365-2133.1990.tb14726.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Patch-test responses to serially diluted nickel sulphate and potassium dichromate solutions in patients with nickel and chrome sensitivity were assessed by pulsed A-scan ultrasound to determine skin thickness and laser-Doppler flowmeter techniques to evaluate blood flow, as well as clinical scoring. There was a relationship between the dose of antigen and the test responses as measured by ultrasound and laser-Doppler flowmeter techniques in both nickel and chrome sensitive patients. Our data suggest that both techniques may be useful in the detection of allergic contact dermatitis in which there is a doubtful patch-test reaction as well as in experimental sensitization studies.
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页码：491 / 499
页数：9
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