D-ASPARTATE OXIDASE, A PEROXISOMAL ENZYME IN LIVER OF RAT AND MAN

被引：90
|
作者：
VANVELDHOVEN, PP
BREES, C
MANNAERTS, GP
机构：
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1073卷 / 01期
关键词：
PEROXISOME; OXIDASE; DICARBOXYLIC AMINO ACID; ZELLWEGER SYNDROME; EXCITOTOXICITY; (HUMAN LIVER);
D O I：
10.1016/0304-4165(91)90203-S
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
By means of subcellular fractionation D-aspartate oxidase was shown to be localized in peroxisomes in rat and human liver. The oxidase from both sources was most active on D-aspartate and N-methyl-D-aspartate. In different rat tissues, the highest enzyme activity was found in kidney, followed by liver and brain. In these tissues, oxidase activities became detectable 1-4 days after birth, reaching adult values after 4 weeks. Analysis of liver samples from patients with Zellweger syndrome, a generalized peroxisomal dysfunction, demonstrated no significant deficiency of this particular oxidase.
引用
收藏
页码：203 / 208
页数：6
相关论文
共 50 条
  • [31] COMPETITIVE INHIBITORS OF BEEF KIDNEY D-ASPARTATE OXIDASE
    RINALDI, A
    CRIFO, C
    [J]. BOLLETTINO DELLA SOCIETA ITALIANA DI BIOLOGIA SPERIMENTALE, 1969, 45 (15): : 1058 - &
  • [32] THE KINETIC MECHANISM OF BEEF KIDNEY D-ASPARTATE OXIDASE
    NEGRI, A
    MASSEY, V
    WILLIAMS, CH
    SCHOPFER, LM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1988, 263 (27) : 13557 - 13563
  • [33] No association between the D-aspartate oxidase locus and schizophrenia
    Abou Jamra, Rami
    Georgi, Alexander
    Suliman, Husam
    Klein, Katrin
    Villela, Angela Wolf
    Schulze, Thomas G.
    Propping, Peter
    Cichon, Sven
    Rietschel, Marcella
    Noethen, Markus M.
    Schumacher, Johannes
    [J]. PSYCHIATRIC GENETICS, 2009, 19 (01) : 56 - 56
  • [34] OXIDATION OF S-CARBOXYMETHYLCYSTEINE BY D-ASPARTATE OXIDASE
    RINALDI, A
    FADDA, MB
    PICCALUGA, G
    MARCO, CD
    [J]. ITALIAN JOURNAL OF BIOCHEMISTRY, 1973, 22 (01): : 46 - 54
  • [35] COMPETITIVE INHIBITORS OF D-ASPARTATE OXIDASE OF HORSE KIDNEY
    RINALDI, A
    FANNI, I
    [J]. BOLLETTINO DELLA SOCIETA ITALIANA DI BIOLOGIA SPERIMENTALE, 1970, 46 (20A): : 234 - &
  • [36] PRESENCE OF D-ASPARTATE OXIDASE AND FREE D-ASPARTATE IN AMPHIBIAN (XENOPUS-LAEVIS, CYNOPS-PYRRHOGASTER) TISSUES
    KERA, Y
    NAGASAKI, H
    IWASHIMA, A
    YAMADA, RH
    [J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1992, 103 (02): : 345 - 348
  • [37] PARTIAL PURIFICATION OF D-ASPARTATE OXIDASE FROM BEEF KIDNEY
    RINALDI, A
    DEMARCO, C
    [J]. BOLLETTINO DELLA SOCIETA ITALIANA DI BIOLOGIA SPERIMENTALE, 1969, 45 (15): : 1055 - &
  • [38] d-Aspartate oxidase: distribution, functions, properties, and biotechnological applications
    Takahashi, Shouji
    [J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2020, 104 (07) : 2883 - 2895
  • [39] Immunohistochemical localization of d-aspartate oxidase in porcine peripheral tissues
    Atsushi Yamamoto
    Hiroyuki Tanaka
    Tetsuo Ishida
    Kihachiro Horiike
    [J]. Amino Acids, 2011, 41 : 529 - 536
  • [40] D-ASPARTATE OXIDASE IN MAMMALIAN BRAIN AND CHOROID-PLEXUS
    YUSKO, SC
    NEIMS, AH
    [J]. JOURNAL OF NEUROCHEMISTRY, 1973, 21 (04) : 1037 - 1039
12345