D-ASPARTATE OXIDASE, A PEROXISOMAL ENZYME IN LIVER OF RAT AND MAN

被引：90
|
作者：
VANVELDHOVEN, PP
BREES, C
MANNAERTS, GP
机构：
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1073卷 / 01期
关键词：
PEROXISOME; OXIDASE; DICARBOXYLIC AMINO ACID; ZELLWEGER SYNDROME; EXCITOTOXICITY; (HUMAN LIVER);
D O I：
10.1016/0304-4165(91)90203-S
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
By means of subcellular fractionation D-aspartate oxidase was shown to be localized in peroxisomes in rat and human liver. The oxidase from both sources was most active on D-aspartate and N-methyl-D-aspartate. In different rat tissues, the highest enzyme activity was found in kidney, followed by liver and brain. In these tissues, oxidase activities became detectable 1-4 days after birth, reaching adult values after 4 weeks. Analysis of liver samples from patients with Zellweger syndrome, a generalized peroxisomal dysfunction, demonstrated no significant deficiency of this particular oxidase.
引用
收藏
页码：203 / 208
页数：6
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