D-ASPARTATE OXIDASE, A PEROXISOMAL ENZYME IN LIVER OF RAT AND MAN

被引：90
|
作者：
VANVELDHOVEN, PP
BREES, C
MANNAERTS, GP
机构：
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1073卷 / 01期
关键词：
PEROXISOME; OXIDASE; DICARBOXYLIC AMINO ACID; ZELLWEGER SYNDROME; EXCITOTOXICITY; (HUMAN LIVER);
D O I：
10.1016/0304-4165(91)90203-S
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
By means of subcellular fractionation D-aspartate oxidase was shown to be localized in peroxisomes in rat and human liver. The oxidase from both sources was most active on D-aspartate and N-methyl-D-aspartate. In different rat tissues, the highest enzyme activity was found in kidney, followed by liver and brain. In these tissues, oxidase activities became detectable 1-4 days after birth, reaching adult values after 4 weeks. Analysis of liver samples from patients with Zellweger syndrome, a generalized peroxisomal dysfunction, demonstrated no significant deficiency of this particular oxidase.
引用
收藏
页码：203 / 208
页数：6
相关论文
共 50 条
  • [1] D-Aspartate Oxidase: The Sole Catabolic Enzyme Acting on Free D-Aspartate in Mammals
    Katane, Masumi
    Homma, Hiroshi
    [J]. CHEMISTRY & BIODIVERSITY, 2010, 7 (06) : 1435 - 1449
  • [2] Rat D-aspartate oxidase is more similar to the human enzyme than the mouse enzyme
    Katane, Masumi
    Kuwabara, Hisashi
    Nakayama, Kazuki
    Saitoh, Yasuaki
    Miyamoto, Tetsuya
    Sekine, Masae
    Homma, Hiroshi
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2018, 1866 (07): : 806 - 812
  • [3] ADMINISTRATION OF D-ASPARTATE INCREASES D-ASPARTATE OXIDASE ACTIVITY IN MOUSE-LIVER
    YAMADA, R
    NAGASAKI, H
    NAGATA, Y
    WAKABAYASHI, Y
    IWASHIMA, A
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 990 (03) : 325 - 328
  • [4] Peroxisomal localization of D-aspartate oxidase and development of peroxisomes in the yeast Cryptococcus humicolus UJ1 grown on D-aspartate
    Kera, Y
    Niino, A
    Ikeda, T
    Okada, H
    Yamada, R
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1998, 1379 (03): : 399 - 405
  • [5] PRESENCE OF D-ASPARTATE OXIDASE IN RAT-LIVER AND MOUSE-TISSUES
    YAMADA, R
    NAGASAKI, H
    WAKABAYASHI, Y
    IWASHIMA, A
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 965 (2-3) : 202 - 205
  • [6] Structure and kinetic properties of human d-aspartate oxidase, the enzyme-controlling d-aspartate levels in brain
    Molla, Gianluca
    Chaves-Sanjuan, Antonio
    Savinelli, Antonio
    Nardini, Marco
    Pollegioni, Loredano
    [J]. FASEB JOURNAL, 2020, 34 (01): : 1182 - 1197
  • [7] Human D-aspartate Oxidase: A Key Player in D-aspartate Metabolism
    Pollegioni, Loredano
    Molla, Gianluca
    Sacchi, Silvia
    Murtas, Giulia
    [J]. FRONTIERS IN MOLECULAR BIOSCIENCES, 2021, 8
  • [8] D-ASPARTATE OXIDASE OF KIDNEY
    DIXON, M
    KENWORTHY, P
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1967, 146 (01) : 54 - +
  • [9] DISTRIBUTION OF D-ASPARTATE OXIDASE IN LIVER AND KIDNEY OF VARIOUS MAMMALS
    DEMARCO, C
    CRIFO, C
    RINALDI, A
    COLETTA, M
    [J]. ENZYMOLOGIA, 1969, 36 (02) : 111 - &
  • [10] COMPETITIVE INHIBITORS OF D-ASPARTATE OXIDASE
    DEMARCO, C
    RINALDI, A
    CRIFO, C
    [J]. PHYSIOLOGICAL CHEMISTRY AND PHYSICS, 1969, 1 (05): : 473 - &
12345