INHIBITION OF GLYCINE N-METHYLTRANSFERASE ACTIVITY BY FOLATE DERIVATIVES - IMPLICATIONS FOR REGULATION OF METHYL-GROUP METABOLISM

被引:150
|
作者
WAGNER, C [1 ]
BRIGGS, WT [1 ]
COOK, RJ [1 ]
机构
[1] VET ADM MED CTR,RES SERV,NASHVILLE,TN 37203
关键词
D O I
10.1016/S0006-291X(85)80006-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:746 / 752
页数:7
相关论文
共 50 条
  • [32] Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate
    Luka, Zigmund
    Pakhomova, Svetlana
    Loukachevitch, Lioudmila V.
    Newcomer, Marcia E.
    Wagner, Conrad
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2012, 1824 (02): : 286 - 291
  • [33] Role of Glycine N-Methyltransferase in the Regulation of T-Cell Responses in Experimental Autoimmune Encephalomyelitis
    Chung-Hsien Li
    Ming-Hong Lin
    Shih-Han Chu
    Pang-Hsien Tu
    Cheng-Chieh Fang
    Chia-Hung Yen
    Peir-In Liang
    Jason C. Huang
    Yu-Chia Su
    Huey-Kang Sytwu
    Yi-Ming Arthur Chen
    Molecular Medicine, 2014, 20 : 684 - 696
  • [34] Role of Glycine N-Methyltransferase in the Regulation of T-Cell Responses in Experimental Autoimmune Encephalomyelitis
    Li, Chung-Hsien
    Lin, Ming-Hong
    Chu, Shih-Han
    Tu, Pang-Hsien
    Fang, Cheng-Chieh
    Yen, Chia-Hung
    Liang, Peir-In
    Huang, Jason C.
    Su, Yu-Chia
    Sytwu, Huey-Kang
    Chen, Yi-Ming Arthur
    MOLECULAR MEDICINE, 2014, 20 : 684 - 696
  • [35] Nicotinamide N-Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism
    Hong, Shangyu
    Zhai, Bo
    Pissios, Pavlos
    BIOCHEMISTRY, 2018, 57 (40) : 5775 - 5779
  • [36] 5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase
    Luka, Zigmund
    Pakhomova, Svetlana
    Loukachevitch, Lioudmila V.
    Egli, Martin
    Newcomer, Marcia E.
    Wagner, Conrad
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (06) : 4069 - 4075
  • [37] REGULATION OF ADRENAL PHENYLETHANOLAMINE N-METHYLTRANSFERASE ACTIVITY IN 3 INBRED MOUSE STRAINS
    CIARANELLO, RD
    BARCHAS, JD
    DORNBUSCH, JN
    MOLECULAR PHARMACOLOGY, 1972, 8 (05) : 511 - +
  • [38] Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect
    Yen, Chia-Hung
    Chen, Yi-Ming
    CANCER RESEARCH, 2009, 69
  • [39] Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect
    Yen, Chia-Hung
    Hung, Jung-Hsien
    Ueng, Yune-Fang
    Liu, Shih-Ping
    Chen, Shih-Yin
    Liu, Hsiao-Han
    Chou, Teh-Ying
    Tsai, Ting-Fen
    Darbha, Ramalakshmi
    Hsieh, Ling-Ling
    Chen, Yi-Ming Arthur
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2009, 235 (03) : 296 - 304
  • [40] Vitamin A and its derivatives induce hepatic glycine N-methyltransferase (GNMT) and hypomethylation of DNA in rats.
    Rowling, MJ
    McMullen, MH
    Schalinske, KL
    FASEB JOURNAL, 2002, 16 (05): : A744 - A744