PARADOXICAL SLEEP-DEPRIVATION INCREASES GLUTAMINE-SYNTHETASE IN RAT-BRAIN

被引：0
|
作者：
SALLANON, M
TOURET, M
DIDIERBAZES, M
BELIN, MF
TARDY, M
JOUVET, M
机构：
[1] UFR ALEXIS CARREL,INSERM,CJF 9010,ANAT PATHOL LAB,F-69008 LYON,FRANCE
[2] HOP HENRI MONDOR,INSERM,U282,F-94010 CRETEIL,FRANCE
来源：
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES | 1992年 / 315卷 / 03期
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D O I：
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中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The modifications of glutamine synthetase (GS) level, an enzyme mainly located in astrocytes, were investigated in rat after paradoxical sleep deprivation and during recovery. An immunotitration method was used to evaluate the relative level of GS in brain tissue. At the end of a 24 hrs. paradoxical sleep deprivation, a significant increase in GS level was observed both in the frontoparietal cortex and the locus coeruleus area. 4 hrs. later, during recovery, the GS level returned to control level in the cortex but was lower in the locus coeruleus area.
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页码：109 / 114
页数：6
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