A MOUSE MODEL FOR TESTING THE PATHOGENICITY OF EQUINE HERPES VIRUS-1 STRAINS

被引：25
|
作者：
VANWOENSEL, PAM
GOOVAERTS, D
MARKX, D
VISSER, N
机构：
[1] Department of Virological Research and Development, Internet International B.V., 5831 AN Boxmeer
来源：
JOURNAL OF VIROLOGICAL METHODS | 1995年 / 54卷 / 01期
关键词：
EQUINE HERPES VIRUS-1 (EHV-1); MOUSE MODEL; PATHOGENICITY;
D O I：
10.1016/0166-0934(95)00024-O
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A mouse model was developed for testing the pathogenicity of equine herpes virus-1 (EHV-1) strains. The model was validated with EHV-1 strains that are known to be of a low or high pathogenicity in horses. From all parameters tested, the safety index, which was calculated from the body weights of the mice after infection, proved to be the best predictive parameter. When this parameter was used, good and reliable correlations were found with the pathogenicity of the EHV-1 strains in horses. This method enabled the differentiation between two experimental EHV-1 strains whose genetic backgrounds were supposedly equal.
引用
收藏
页码：39 / 49
页数：11
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