A MOUSE MODEL FOR TESTING THE PATHOGENICITY OF EQUINE HERPES VIRUS-1 STRAINS

被引：25
|
作者：
VANWOENSEL, PAM
GOOVAERTS, D
MARKX, D
VISSER, N
机构：
[1] Department of Virological Research and Development, Internet International B.V., 5831 AN Boxmeer
来源：
JOURNAL OF VIROLOGICAL METHODS | 1995年 / 54卷 / 01期
关键词：
EQUINE HERPES VIRUS-1 (EHV-1); MOUSE MODEL; PATHOGENICITY;
D O I：
10.1016/0166-0934(95)00024-O
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A mouse model was developed for testing the pathogenicity of equine herpes virus-1 (EHV-1) strains. The model was validated with EHV-1 strains that are known to be of a low or high pathogenicity in horses. From all parameters tested, the safety index, which was calculated from the body weights of the mice after infection, proved to be the best predictive parameter. When this parameter was used, good and reliable correlations were found with the pathogenicity of the EHV-1 strains in horses. This method enabled the differentiation between two experimental EHV-1 strains whose genetic backgrounds were supposedly equal.
引用
收藏
页码：39 / 49
页数：11
相关论文
共 50 条
  • [21] Selective vulnerability of mouse CNS neurons to latent infection with a neuroattenuated herpes simplex virus-1
    Kesari, S
    Lee, VMY
    Brown, SM
    Trojanowski, JQ
    Fraser, NW
    JOURNAL OF NEUROSCIENCE, 1996, 16 (18): : 5644 - 5653
  • [22] HERPES-SIMPLEX VIRUS-1 INFECTION OF THE CERVIX
    PEUTHERER, JF
    SMITH, IW
    HUNTER, JM
    LANCET, 1981, 2 (8258): : 1285 - 1285
  • [23] PATHOGENESIS OF BOVINE HERPES VIRUS-1 INFECTION OF CATTLE
    BERGMANN, H
    KARGE, E
    MONATSHEFTE FUR VETERINARMEDIZIN, 1989, 44 (11): : 365 - 368
  • [24] Corneal latency and transmission of herpes simplex virus-1
    Farooq, Asim V.
    Shukla, Deepak
    FUTURE VIROLOGY, 2011, 6 (01) : 101 - 108
  • [25] Immune responses to primary infection with indigenous strain of equine herpes virus-1 in pregnant BALB/c mice
    Virmani, N
    Singh, BK
    Batra, M
    Verma, PC
    Panisup, AS
    INDIAN JOURNAL OF ANIMAL SCIENCES, 2005, 75 (12): : 1385 - 1387
  • [26] Canine herpes virus-1 in chile:: Biological properties
    Navarro, C
    Celedón, M
    Pizarro, J
    Gaggero, A
    ARCHIVOS DE MEDICINA VETERINARIA, 2005, 37 (02) : 133 - 137
  • [27] VARIABILITY IN STRUCTURAL POLYPEPTIDES OF HERPES-SIMPLEX VIRUS-1 STRAINS - POTENTIAL APPLICATION IN MOLECULAR EPIDEMIOLOGY
    PEREIRA, L
    CASSAI, E
    HONESS, RW
    ROIZMAN, B
    TERNI, M
    NAHMIAS, A
    INFECTION AND IMMUNITY, 1976, 13 (01) : 211 - 220
  • [28] Murine Hepatitis Virus-1 Mouse Model to Study Hepatic Encephalopathy
    Jayakumar, Arumugam R.
    Paidas, Michael J.
    Hussain, Hussain
    Ramamoorthy, Rajalakshmi
    Masciarella, Andrew D.
    Di Gregorio, Dibe M.
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2023, 118 (9S): : S22 - S23
  • [29] CERTAIN FEATURES OF VARIOUS STRAINS OF HERPES VIRUSES .2. PATHOGENICITY AND MORPHOLOGICAL FEATURES OF VARIOUS STRAINS OF HERPES VIRUS
    SHUBLADZE, A
    VANAG, AI
    MAYEVSKAYA, TM
    PROBLEMS OF VIROLOGY USSR, 1961, 6 (03): : 306 - &
  • [30] Postpartum Neonatal Disseminated Herpes Simplex Virus-1 Infection in Which Herpes Simplex Virus-1 Was Detected in Mother's Breast Milk
    Takagi, Yuhi
    Fujita, Yuji
    Otaka, Tomohiro
    Kano, Yuji
    Fukushima, Keitaro
    Sato, Yuya
    Yoshihara, Shigemi
    INDIAN JOURNAL OF PEDIATRICS, 2023, 90 (05): : 510 - 512
12345