DETERMINATION OF BENZYDAMINE AND ITS N-OXIDE IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：25
|
作者：
BALDOCK, GA
BRODIE, RR
CHASSEAUD, LF
TAYLOR, T
机构：
[1] Department of Metabolism and Pharmacokinetics, Huntingdon Research Centre, Huntingdon, Cambridgeshire
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 529卷 / 01期
关键词：
D O I：
10.1016/S0378-4347(00)83812-8
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple, sensitive and selective method for the determination of benzydamine in human plasma and urine, and for benzydamine N-oxide in urine, has been developed using high-performance liquid chromatography in the reversed-phase mode. The limit of reliable determination of benzydamine in plasma was 0.5 ng/ml and that in urine 1 ng/ml; the limit of reliable determination of benzydamine N-oxide in urine was 50 ng/ml. The method has been successfully applied to the analysis of these compounds in biological fluids after administration of intravenous and oral doses of benzydamine to human volunteers. © 1990.
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页码：113 / 123
页数：11
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