DETERMINATION OF BENZYDAMINE AND ITS N-OXIDE IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：25
|
作者：
BALDOCK, GA
BRODIE, RR
CHASSEAUD, LF
TAYLOR, T
机构：
[1] Department of Metabolism and Pharmacokinetics, Huntingdon Research Centre, Huntingdon, Cambridgeshire
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 529卷 / 01期
关键词：
D O I：
10.1016/S0378-4347(00)83812-8
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple, sensitive and selective method for the determination of benzydamine in human plasma and urine, and for benzydamine N-oxide in urine, has been developed using high-performance liquid chromatography in the reversed-phase mode. The limit of reliable determination of benzydamine in plasma was 0.5 ng/ml and that in urine 1 ng/ml; the limit of reliable determination of benzydamine N-oxide in urine was 50 ng/ml. The method has been successfully applied to the analysis of these compounds in biological fluids after administration of intravenous and oral doses of benzydamine to human volunteers. © 1990.
引用
收藏
页码：113 / 123
页数：11
相关论文
共 50 条
  • [21] DETERMINATION OF THE NEW FLUOROQUINOLONE BALOFLOXACIN AND ITS METABOLITES IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    NAKAGAWA, T
    ISHIGAI, M
    HIRAMATSU, Y
    KINOSHITA, H
    ISHITANI, Y
    OHKUBO, K
    OKAZAKI, A
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1995, 45-1 (06): : 716 - 718
  • [22] SIMULTANEOUS DETERMINATION OF MORICIZINE AND ITS SULFOXIDATION METABOLITES IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    YANG, JM
    CHAN, K
    JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1995, 663 (01): : 172 - 176
  • [23] SPECIFIC DETERMINATION OF HYDROQUINIDINE AND ITS MAJOR METABOLITES IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    RESPLANDY, G
    ROUX, A
    DUPAS, I
    VIEL, C
    PLAT, M
    FLOUVAT, B
    JOURNAL OF LIQUID CHROMATOGRAPHY, 1988, 11 (07): : 1495 - 1511
  • [24] DETERMINATION OF LOMEFLOXACIN IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND A MICROBIOLOGICAL METHOD
    SHIBL, AM
    TAWFIK, AF
    ELHOUFY, S
    ALSHAMMARY, FJ
    JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 1991, 16 (05) : 353 - 359
  • [25] SIMPLE METHOD FOR THE DETERMINATION OF RHEIN IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    SPRINGOLO, V
    COPPI, G
    JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1988, 428 (01): : 173 - 177
  • [26] DETERMINATION OF PHOLCODINE IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUORESCENCE DETECTION
    CHEN, ZR
    SIEBERT, DM
    SOMOGYI, AA
    BOCHNER, F
    JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1988, 424 (01): : 170 - 176
  • [27] QUANTITATIVE-DETERMINATION OF PTERINS IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    STEA, B
    HALPERN, RM
    HALPERN, BC
    SMITH, RA
    JOURNAL OF CHROMATOGRAPHY, 1980, 188 (02): : 363 - 375
  • [28] DETERMINATION OF FLURBIPROFEN IN DOSAGE FORM AND IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    BABHAIR, SA
    JOURNAL OF LIQUID CHROMATOGRAPHY, 1988, 11 (02): : 463 - 473
  • [29] DETERMINATION OF CAFFEINE AND DIMETHYLXANTHINES IN BIOLOGICAL-FLUIDS AND TISSUES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    NAKAZAWA, K
    TANAKA, H
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1985, 105 (09): : 848 - 854
  • [30] DETERMINATION OF ISOFLOXYTHEPIN IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUOROMETRIC DETECTION
    FUKUHARA, K
    MATSUKI, Y
    KURATA, Y
    EBISAWA, H
    NAMBARA, T
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1988, 108 (05): : 454 - 457
12345