Development and characterization of solid lipid nanoparticles for enhancement of oral bioavailability of Raloxifene

被引：15
|
作者：
Divyakant, B. Patel [1 ]
Valay, R. Modi [1 ]
Alok, N. Thakkar [1 ]
Arpita, A. Patel [1 ]
Hetal, P. Thakkar [1 ]
机构：
[1] Maharaja Sayajirao Univ Baroda, Fac Engn & Technol, Dept Pharm, Vadodara, Gujarat, India
来源：
JOURNAL OF PHARMACY AND BIOALLIED SCIENCES | 2012年 / 4卷 / 05期
关键词：
Drug entrapment; estrogen; solvent emulsification; zeta potential;
D O I：
10.4103/0975-7406.94121
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The objective of this study was to increase the oral bioavailability of Raloxifene having an absolute bioavailability only 2% due to extensive first pass hepatic metabolism by incorporating it in Solid Lipid Nanoparticles (SLNs). The optimized RSLNs prepared by Ultrasonic Emulsification and Low Temperature Solidification method showed the mean particle size, zeta potential and percentage drug entrapment of 101.4 +/- 3.5 nm, 19.4 +/- 0.279 mv, 97.67 +/- 1.02% respectively. The in-vitro intestinal permeability study indicated significantly higher permeation of the RSLNs than the marketed preparation. The in-vivo studies showed that pharmacokinetic parameters for the RSLNs were 3.5 times higher than the marketed preparation indicating significant increase in the oral bioavailability of the Raloxifene.
引用
收藏
页码：S14 / S16
页数：3
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