Formulation Design, Characterization and In-Vivo Assessment of Cefixime Loaded Binary Solid Lipid Nanoparticles to Enhance Oral Bioavailability

被引:0
|
作者
Kamran, Mahwish [1 ]
Khan, Mir Azam [1 ]
Shafique, Muhammad [3 ]
Alotaibi, Ghallab [3 ]
Al Mouslem, Abdulaziz [4 ]
Rehman, Maqsood [1 ,2 ]
Khan, Muhammad Asghar [1 ]
Abdullah [1 ]
Gul, Sumaira [5 ]
机构
[1] Univ Malakand, Dept Pharm, Chakdara 18800, Khyber Pakhtunk, Pakistan
[2] UCL, Sch Pharm, Dept Pharmaceut, London WC1N 1AX, England
[3] Shaqra Univ, Coll Pharm Boys, Dept Pharmaceut Sci, Al Dawadmi Campus, Shaqra 15572, Saudi Arabia
[4] King Faisal Univ, Coll Clin Pharm, Dept Pharmaceut Sci, Al Hasa 31982, Saudi Arabia
[5] Abdul Wali Khan Univ, Dept Pharm, Mardan 23200, Pakistan
关键词
Micro-Emulsion; Binary SLNs; Relative Bioavailability; In-Vitro Release; In-Vivo Evaluation; Dosage Form; CONTROLLED DRUG-DELIVERY; VITRO; OPTIMIZATION; STATE; CARRIERS; RELEASE; SLN; NANOMEDICINE; NANOCRYSTALS; PERFORMANCE;
D O I
10.1166/jbn.2022.3313
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Cefixime; widely employed cephalosporin antibiotic is unfortunately coupled to poor water solubility with resultant low oral bioavailability issues. To solve this problem micro-emulsion technique was used to fabricate binary SLNs using blend of solid and liquid lipids, surfactant as well as co- surfactant. The optimized nano suspension was characterized followed by modification to solidified dosage form. During characterization, optimized nano-suspension (CFX-4) produced particle size 189 +/- 2.1 nm with PDI 0.310 +/- 0.02 as well as -33.9 +/- 2 mV zeta potential. Scanning electron microscopy (SEM) presented nearly identical and spherical shaped particles. Differential scanning calorimetry and X-ray powder diffraction analysis ascertained decrease in drug's crystallinity. In-vitro release of drug pursued zero-order characteristics and demonstrated non-fickian pattern of diffusion. The freeze dried nano suspension (CFX-4) was transformed to capsule dosage form to perform comparison based in-vivo studies. In-vivo evaluation corresponded to 2.20-fold and 2.11-fold enhancement in relative bioavailability of CFX nano-formulation (CFX-4) as well as the prepared capsules respectively in contrast to the commercialized product (Cefiget (R)). In general; the obtained results substantiated superior oral bioavailability along with sustained pattern of drug release for CFX loaded binary nano particles. Thus, binary SLNs could be employed as a resourceful drug carrier for oral CFX delivery.
引用
收藏
页码:1215 / 1226
页数:12
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