CONSECUTIVE GLIOBLASTOMA AND B-CELL NON-HODGKINS-LYMPHOMA IN A YOUNG-CHILD WITH VONRECKLINGHAUSENS NEUROFIBROMATOSIS

被引：8

作者：

UYTTEBROECK, A ^{[1
]}

LEGIUS, E ^{[1
]}

BROCK, P ^{[1
]}

VANDECASSEYE, W ^{[1
]}

CASAER, P ^{[1
]}

CASTEELSVANDAELE, M ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN, DEPT PAEDIAT, B-3030 HEVERLEE, BELGIUM

来源：

MEDICAL AND PEDIATRIC ONCOLOGY | 1995年 / 24卷 / 01期

关键词：

NEUROFIBROMATOSIS; MULTIPLE MALIGNANCIES; CHILDHOOD; NON-HODGKINS LYMPHOMA; GLIOBLASTOMA; TUMOR SUPPRESSOR GENE;

D O I：

10.1002/mpo.2950240110

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A young child with neurofibromatosis type 1 (NF1) is reported who developed two primary malignancies: a glioblastoma, followed 6 months later by an abdominal B cell non-Hodgkin's lymphoma. The child is now 4.5 years off treatment and disease free, but has developed progressive and severe psychomotor retardation as sequelae. The NF1 gene is known to act as a tumor suppressor gene. The possible mechanisms leading to the occurrence of a second primary tumor in this child are discussed. (C) Wiley-Liss, Inc.

引用

页码：46 / 49

页数：4

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