A young child with neurofibromatosis type 1 (NF1) is reported who developed two primary malignancies: a glioblastoma, followed 6 months later by an abdominal B cell non-Hodgkin's lymphoma. The child is now 4.5 years off treatment and disease free, but has developed progressive and severe psychomotor retardation as sequelae. The NF1 gene is known to act as a tumor suppressor gene. The possible mechanisms leading to the occurrence of a second primary tumor in this child are discussed. (C) Wiley-Liss, Inc.
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NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21702NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21702
LI, CCH
OCONNELL, CD
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NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21702NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21702
OCONNELL, CD
BECKWITH, M
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NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21702NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21702
BECKWITH, M
LONGO, DL
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NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21702NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21702
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UNIV MED & DENT NEW JERSEY,COOPER HOSP,MED CTR,ROBERT WOOD JOHNSON MED SCH,DEPT MED,DIV INFECT D,CAMDEN,NJ 08103UNIV MED & DENT NEW JERSEY,COOPER HOSP,MED CTR,ROBERT WOOD JOHNSON MED SCH,DEPT MED,DIV INFECT D,CAMDEN,NJ 08103
BAXTER, JD
DINUBILE, MJ
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UNIV MED & DENT NEW JERSEY,COOPER HOSP,MED CTR,ROBERT WOOD JOHNSON MED SCH,DEPT MED,DIV INFECT D,CAMDEN,NJ 08103UNIV MED & DENT NEW JERSEY,COOPER HOSP,MED CTR,ROBERT WOOD JOHNSON MED SCH,DEPT MED,DIV INFECT D,CAMDEN,NJ 08103