INVESTIGATION OF THE DIMETHYLSULFOXIDE TRIFLUOROACETIC-ACID OXIDATION SYSTEM FOR THE SYNTHESIS OF CYSTINE-CONTAINING PEPTIDES

被引：0
|
作者：
KOIDE, T [1 ]
OTAKA, A [1 ]
FUJII, N [1 ]
机构：
[1] KYOTO UNIV, FAC PHARMACEUT SCI, SAKYO KU, KYOTO 60601, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1993年 / 41卷 / 06期
关键词：
CYSTINE-CONTAINING PEPTIDE; DISULFIDE BOND-FORMATION; DIMETHYLSULFOXIDE; OXYTOCIN; CALCITONIN GENE-RELATED PEPTIDE; APAMIN;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Disulfide bonds of peptides were effectively established between S-protected cysteine residues as well as free cysteine residues by the action of dimethylsulfoxide in trifluoroacetic acid. Oxytocin and alpha-human calcitonin gene-related peptide were synthesized using this oxidation system. The feasibility of this method for the formation of two disulfide bridges of apamin was also examined.
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页码：1030 / 1034
页数：5
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