INVESTIGATION OF THE DIMETHYLSULFOXIDE TRIFLUOROACETIC-ACID OXIDATION SYSTEM FOR THE SYNTHESIS OF CYSTINE-CONTAINING PEPTIDES

被引：0

作者：

KOIDE, T ^{[1
]}

OTAKA, A ^{[1
]}

FUJII, N ^{[1
]}

机构：

[1] KYOTO UNIV, FAC PHARMACEUT SCI, SAKYO KU, KYOTO 60601, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1993年 / 41卷 / 06期

关键词：

CYSTINE-CONTAINING PEPTIDE; DISULFIDE BOND-FORMATION; DIMETHYLSULFOXIDE; OXYTOCIN; CALCITONIN GENE-RELATED PEPTIDE; APAMIN;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Disulfide bonds of peptides were effectively established between S-protected cysteine residues as well as free cysteine residues by the action of dimethylsulfoxide in trifluoroacetic acid. Oxytocin and alpha-human calcitonin gene-related peptide were synthesized using this oxidation system. The feasibility of this method for the formation of two disulfide bridges of apamin was also examined.

引用

页码：1030 / 1034

页数：5

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