EVALUATION OF MONOCLONAL-ANTIBODIES WITH SPECIFICITY FOR THE HUMAN PLATELET HPA-1 ALLOTYPES

被引：0
|
作者：
DIAZ, M
RYCKEWAERT, JJ
MASSON, D
BENSA, JC
MARGUERIE, G
机构：
[1] CEN, DEPT BIOL MOLEC & STRUCT,INSERM,U217,HEMATOL LAB, 85X, F-38041 GRENOBLE, FRANCE
[2] CTR TRANSFUS SANGUINE GRENOBLE, LA TRONCHE, FRANCE
来源：
VOX SANGUINIS | 1993年 / 65卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Two mouse monoclonal antibodies have been characterized. Both antibodies specifically recognized the amino acid sequences which are responsible for the presence of the HPA-la and HPA-lb alloantigens at the surface of human platelet. The monoclonality allied with an exquisite specificity of these antibodies allow a perfect typing of platelet HPA-1 status. A fast and reliable Elisa assay which fulfills all the needs and requirements of hematology laboratories has been set up and is described here. The Elisa assay has been tested on a population of 689 blood donors. The results agreed with the known phenotypic frequencies of the HPA-1 alloantigens.
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页码：219 / 222
页数：4
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