EVALUATION OF MONOCLONAL-ANTIBODIES WITH SPECIFICITY FOR THE HUMAN PLATELET HPA-1 ALLOTYPES

被引：0
|
作者：
DIAZ, M
RYCKEWAERT, JJ
MASSON, D
BENSA, JC
MARGUERIE, G
机构：
[1] CEN, DEPT BIOL MOLEC & STRUCT,INSERM,U217,HEMATOL LAB, 85X, F-38041 GRENOBLE, FRANCE
[2] CTR TRANSFUS SANGUINE GRENOBLE, LA TRONCHE, FRANCE
来源：
VOX SANGUINIS | 1993年 / 65卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Two mouse monoclonal antibodies have been characterized. Both antibodies specifically recognized the amino acid sequences which are responsible for the presence of the HPA-la and HPA-lb alloantigens at the surface of human platelet. The monoclonality allied with an exquisite specificity of these antibodies allow a perfect typing of platelet HPA-1 status. A fast and reliable Elisa assay which fulfills all the needs and requirements of hematology laboratories has been set up and is described here. The Elisa assay has been tested on a population of 689 blood donors. The results agreed with the known phenotypic frequencies of the HPA-1 alloantigens.
引用
收藏
页码：219 / 222
页数：4
相关论文
共 50 条
  • [31] HUMAN MONOCLONAL-ANTIBODIES
    LARRICK, JW
    GAVILONDO, J
    INTERFERON Y BIOTECNOLOGIA, 1989, 6 (02): : 111 - 131
  • [32] HUMAN MONOCLONAL-ANTIBODIES
    DESGRANGES, C
    BIOFUTUR, 1986, (44) : 23 - 25
  • [33] HUMAN MONOCLONAL-ANTIBODIES
    SIKORA, K
    NEVILLE, AM
    NATURE, 1982, 300 (5890) : 316 - 317
  • [34] HUMAN PLATELET SPECIFIC ANTIGEN (HPA-1) POLYMORPHISM IN MALAY ISCHEMIC STROKE PATIENTS
    Mustaffa, R.
    Rifin, Mohd S.
    Hassan, R.
    Mahmood, Wan W. H.
    Ghazali, S.
    VOX SANGUINIS, 2009, 97 : 128 - 128
  • [35] Monoclonal antibody MDP-1 identifies an epitope near the HPA-1 domain on platelet glycoprotein IIIa that modulates platelet function
    Mattson, JC
    Estry, DW
    Ciucu, E
    Westley, S
    Farrah, D
    Rea, E
    Chen, J
    THROMBOSIS AND HAEMOSTASIS, 1999, : 641 - 641
  • [36] HUMAN-HUMAN HYBRIDOMAS PRODUCING MONOCLONAL-ANTIBODIES OF PREDEFINED ANTIGENIC SPECIFICITY
    OLSSON, L
    KAPLAN, HS
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (09): : 5429 - 5431
  • [37] THE SPECIFICITY OF HUMAN-LIVER MEMBRANE LIPOPROTEIN - STUDIES WITH MONOCLONAL-ANTIBODIES
    MURAKAMI, H
    KURIKI, J
    KAKUMU, S
    FUKUI, K
    SAKAMOTO, N
    HEPATOLOGY, 1984, 4 (02) : 192 - 198
  • [38] IMMUNOTHERAPY WITH HUMAN MONOCLONAL-ANTIBODIES - FRAGMENT-A SPECIFICITY OF POLYCLONAL AND MONOCLONAL-ANTIBODIES IS CRUCIAL FOR FULL PROTECTION AGAINST TETANUS TOXIN
    LANG, AB
    CRYZ, SJ
    SCHURCH, U
    GANSS, MT
    BRUDERER, U
    JOURNAL OF IMMUNOLOGY, 1993, 151 (01): : 466 - 472
  • [39] NEW MONOCLONAL-ANTIBODIES WITH HIGH SPECIFICITY FOR HUMAN-MALIGNANT MELANOMA
    SIKORA, LKJ
    PINTO, A
    JERRY, LM
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1985, 26 (MAR): : 291 - 291
  • [40] SPECIFICITY OF MOUSE AND HUMAN MONOCLONAL-ANTIBODIES TO MYELIN-ASSOCIATED GLYCOPROTEIN
    NOBILEORAZIO, E
    HAYS, AP
    LATOV, N
    PERMAN, G
    GOLIER, J
    SHY, ME
    FREDDO, L
    NEUROLOGY, 1984, 34 (10) : 1336 - 1342
12345