Cancer testis antigen and immunotherapy

被引：45

作者：

Krishnadas, Deepa Kolaseri ^{[1
]}

Bai, Fanqi ^{[1
]}

Lucas, Kenneth G. ^{[1
]}

机构：

[1] Univ Louisville, Dept Pediat, Div Hematol Oncol, Louisville, KY 40292 USA

来源：

IMMUNOTARGETS AND THERAPY | 2013年 / 2卷

关键词：

cancer testis antigens; immunotherapy; vaccine;

D O I：

10.2147/ITT.S35570

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The identification of cancer testis (CT) antigens has been an important advance in determining potential targets for cancer immunotherapy. Multiple previous studies have shown that CT antigen vaccines, using both peptides and dendritic cell vaccines, can elicit clinical and immunologic responses in several different tumors. This review details the expression of melanoma antigen family A, 1 (MAGE-A1), melanoma antigen family A, 3 (MAGE-A3), and New York esophageal squamous cell carcinoma-1 (NY-ESO-1) in various malignancies, and presents our current understanding of CT antigen based immunotherapy.

引用

页码：11 / 19

页数：9

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