Cancer testis antigen and immunotherapy

被引：45
|
作者：
Krishnadas, Deepa Kolaseri [1 ]
Bai, Fanqi [1 ]
Lucas, Kenneth G. [1 ]
机构：
[1] Univ Louisville, Dept Pediat, Div Hematol Oncol, Louisville, KY 40292 USA
来源：
IMMUNOTARGETS AND THERAPY | 2013年 / 2卷
关键词：
cancer testis antigens; immunotherapy; vaccine;
D O I：
10.2147/ITT.S35570
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The identification of cancer testis (CT) antigens has been an important advance in determining potential targets for cancer immunotherapy. Multiple previous studies have shown that CT antigen vaccines, using both peptides and dendritic cell vaccines, can elicit clinical and immunologic responses in several different tumors. This review details the expression of melanoma antigen family A, 1 (MAGE-A1), melanoma antigen family A, 3 (MAGE-A3), and New York esophageal squamous cell carcinoma-1 (NY-ESO-1) in various malignancies, and presents our current understanding of CT antigen based immunotherapy.
引用
收藏
页码：11 / 19
页数：9
相关论文
共 50 条
  • [11] XAGE-1b Cancer/Testis Antigen Is a Potential Target for Immunotherapy in Prostate Cancer
    Xie, Chong
    Wang, Guomin
    UROLOGIA INTERNATIONALIS, 2015, 94 (03) : 354 - 362
  • [12] Cancer testis antigen expression and immune responses by prostate cancer patients: Implications for prognosis and immunotherapy
    von Boehmer, L.
    Wild, P.
    Keller, L.
    Hermanns, T.
    Provenzano, M.
    Sais, G.
    Jaeger, E.
    Stenner, F.
    Moch, H.
    Knuth, A.
    JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (15)
  • [13] Adaptive immunotherapy of the advanced prostate cancer - Cancer testis antigen (CTA) as possible target antigens
    Prikler, L
    Scandella, E
    Men, Y
    Engeler, DS
    Diener, PA
    Gillessen, S
    Ludewig, B
    Schmidt, HP
    AKTUELLE UROLOGIE, 2004, 35 (04) : 326 - 330
  • [14] Sperm-associated antigen 9, a novel cancer testis antigen, is a potential target for immunotherapy in epithelial ovarian cancer
    Garg, Manoj
    Chaurasiya, Dipak
    Rana, Ritu
    Jagadish, Nirmala
    Kanojia, Deepika
    Dudha, Namrata
    Kamran, Neha
    Salhan, Sudha
    Bhatnagar, Amar
    Suri, Sushma
    Gupta, Anju
    Suri, Anil
    CLINICAL CANCER RESEARCH, 2007, 13 (05) : 1421 - 1428
  • [15] NY-ESO-1: a promising cancer testis antigen for sarcoma immunotherapy and diagnosis
    Smith, Stephen M.
    Iwenofu, O. Hans
    CHINESE CLINICAL ONCOLOGY, 2018, 7 (04)
  • [16] Leveraging epigenetics to enhance the efficacy of cancer-testis antigen: a potential candidate for immunotherapy
    Gupta, Rashmi
    Jit, Bimal Prasad
    Kumar, Santosh
    Mittan, Sandeep
    Tanwer, Pranay
    Ray, M. D.
    Mathur, Sandeep
    Perumal, Vanamail
    Kumar, Lalit
    Rath, G. K.
    Sharma, Ashok
    EPIGENOMICS, 2022, 14 (14) : 865 - 886
  • [17] TPTE "cancer/testis" antigen is a candidate target for immunotherapy in epithelial ovarian carcinoma.
    Singhal, PK
    Qian, F
    Keitz, B
    Driscoll, D
    Skipper, J
    Simpson, A
    Old, L
    Lele, S
    Odunsi, K
    JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (16) : 186S - 186S
  • [18] BORIS, a novel cancer-testis antigen, is a potential target for immunotherapy in epithelial ovarian cancer.
    Villella, JA
    Qian, F
    Keitz, B
    Driscoll, D
    Skipper, J
    Simpson, A
    Old, L
    Lele, S
    Odunsi, K
    JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (16) : 879S - 879S
  • [19] Sperm Protein 17: Clinical Relevance of a Cancer/Testis Antigen, from Contraception to Cancer Immunotherapy, and Beyond
    Chiriva-Internati, Maurizio
    INTERNATIONAL REVIEWS OF IMMUNOLOGY, 2011, 30 (2-3) : 138 - 149
  • [20] Boris, a novel cancer-testis antigen is a potential target for immunotherapy in epithelial ovarian cancer.
    Villella, JA
    Qian, F
    Keitz, B
    Driscoll, D
    Skipper, J
    Simpson, A
    Old, L
    Lele, S
    Odunsi, K
    JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 2005, 12 (02) : 286A - 287A
12345