STYRENE-7,8-OXIDE IN BLOOD OF WORKERS EXPOSED TO STYRENE

被引：34

作者：

KORN, M ^{[1
]}

GFRORER, W ^{[1
]}

FILSER, JG ^{[1
]}

KESSLER, W ^{[1
]}

机构：

[1] GSF,INST TOXICOL,D-85758 OBERSCHLEISSHEIM,GERMANY

来源：

ARCHIVES OF TOXICOLOGY | 1994年 / 68卷 / 08期

关键词：

STYRENE; STYRENE-7,8-OXIDE; BLOOD CONCENTRATION; MAN; FIELD STUDY; CAPILLARY GAS CHROMATOGRAPHY;

D O I：

10.1007/s002040050107

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

A field study was carried out on 13 workers exposed to styrene vapors at time-weighted average concentrations between 10 and 73 ppm. The reactive intermediate styrene-7,8-oxide was determined in blood samples using a direct gas chromatographic method. Styrene-7,8-oxide concentrations were in the range between 0.9 and 4.1 mu/l blood. Linear correlations were found between styrene-7,8-oxide in blood and styrene in ambient air and blood. For an exposure concentration of 20 ppm styrene (German MAK value) a steady-state level of about 1 mu g styrene-7,8-oxide/l blood was calculated.

引用

页码：524 / 527

页数：4

共 50 条

[41] Role of glutathione S-transferase mu (GSTM1) in styrene-7,8-oxide toxicity and mutagenicity
Shield, AJ
Sanderson, BJS
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2001, 37 (04) : 285 - 289
[42] Influence of GSTT1 genotype on sister chromatid exchange induction by styrene-7,8-oxide in cultured human lymphocytes
Ollikainen, T
Hirvonen, A
Norppa, H
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1998, 31 (04) : 311 - 315
[43] DNA adducts of styrene-7,8-oxide in target and non-target organs for tumor induction in rat and mouse after repeated inhalation exposure to styrene
Otteneder, M
Lutz, U
Lutz, WK
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2002, 500 (1-2) : 111 - 116
[44] Alkylation of anionic DNA bases by styrene 7,8-oxide
Koskinen, M
Schweda, EKH
Hemminki, K
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1999, (11): : 2441 - 2445
[45] Genotoxic effects of styrene-7,8-oxide in human white blood cells:: comet assay in relation to the induction of sister-chromatid exchanges and micronuclei
Laffon, B
Pásaro, E
Méndez, J
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2001, 491 (1-2) : 163 - 172
[46] INVESTIGATION OF STYRENE IN THE LIVER PERFUSION CELL-CULTURE SYSTEM - NO INDICATION OF STYRENE-7,8-OXIDE AS THE PRINCIPAL MUTAGENIC METABOLITE PRODUCED BY THE INTACT RAT-LIVER
BEIJE, B
JENSSEN, D
CHEMICO-BIOLOGICAL INTERACTIONS, 1982, 39 (01) : 57 - 76
[47] Effect of epoxide hydrolase and glutathione S-tranferase genotypes on the induction of micronuclei and DNA damage by styrene-7,8-oxide in vitro
Laffon, B
Pérez-Cadahía, B
Pásaro, E
Méndez, J
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2003, 536 (1-2) : 49 - 59
[48] LIQUID SECONDARY ION MASS-SPECTROMETRIC (LSIMS) MASS MAPPING OF HUMAN-HEMOGLOBIN MODIFIED INVITRO BY STYRENE-7,8-OXIDE
KAUR, S
HOLLANDER, D
HAAS, R
BURLINGAME, AL
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1989, 197 : 38 - AGRO
[49] Enzyme kinetics of styrene-7,8-oxide hydrolysis by recombinant wild type and Glu404Asp mouse mEH in yeast microsomes
Hänel, K
Arand, M
Oesch, F
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2001, 363 (04) : R136 - R136
[50] Styrene 7,8-oxide induces mitochondrial damage and oxidative stress in neurons
Daré, E
Tofighi, R
Nutt, L
Vettori, MV
Emgård, A
Mutti, A
Ceccatelli, S
TOXICOLOGY, 2004, 201 (1-3) : 125 - 132

← 1 2 3 4 5 →