A SHORT AND EFFICIENT SYNTHESIS OF (-)-AMBROX(R) FROM (-)-SCLAREOL USING A RUTHENIUM OXIDE CATALYZED KEY STEP

被引：35
|
作者：
MARTRES, P [1 ]
PERFETTI, P [1 ]
ZAHRA, JP [1 ]
WAEGELL, B [1 ]
GIRAUDI, E [1 ]
PETRZILKA, M [1 ]
机构：
[1] CTR RECH GIVAUDAN ROURE,F-06332 GRASSE,FRANCE
来源：
TETRAHEDRON LETTERS | 1993年 / 34卷 / 04期
关键词：
AMBROX(R); SCLAREOL; RUTHENIUM TETROXIDE;
D O I：
10.1016/S0040-4039(00)61637-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(-)-Ambrox(R)5 has been synthesized in 3 steps from natural (-)-sclareol 1. Depending on the reoxidizing agents and the reaction conditions used in the ruthenium oxide catalyzed key step, overall yields of 79% (NaIO4/RuO4) or 48% (Ca(OCl)2/RuO4-) were observed.
引用
收藏
页码：629 / 632
页数：4
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