A SHORT AND EFFICIENT SYNTHESIS OF (-)-AMBROX(R) FROM (-)-SCLAREOL USING A RUTHENIUM OXIDE CATALYZED KEY STEP

被引：35

作者：

MARTRES, P ^{[1
]}

PERFETTI, P ^{[1
]}

ZAHRA, JP ^{[1
]}

WAEGELL, B ^{[1
]}

GIRAUDI, E ^{[1
]}

PETRZILKA, M ^{[1
]}

机构：

[1] CTR RECH GIVAUDAN ROURE,F-06332 GRASSE,FRANCE

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 04期

关键词：

AMBROX(R); SCLAREOL; RUTHENIUM TETROXIDE;

D O I：

10.1016/S0040-4039(00)61637-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(-)-Ambrox(R)5 has been synthesized in 3 steps from natural (-)-sclareol 1. Depending on the reoxidizing agents and the reaction conditions used in the ruthenium oxide catalyzed key step, overall yields of 79% (NaIO4/RuO4) or 48% (Ca(OCl)2/RuO4-) were observed.

引用

页码：629 / 632

页数：4

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