BRADYKININ POTENTIATES ACETYLCHOLINE-INDUCED RESPONSES IN NATIVE ENDOTHELIAL-CELLS FROM RABBIT AORTA

被引：10

作者：

WANG, XD ^{[1
]}

CHU, W ^{[1
]}

LAU, F ^{[1
]}

VANBREEMEN, C ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,FAC MED,DEPT PHARMACOL & THERAPEUT,VANCOUVER,BC V6T 1G3,CANADA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 213卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.2235

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Membrane potential and intracellular [Ca2+] were measured in freshly isolated rabbit aortic endothelial cells. Acetylcholine (10 mu M) induced transient membrane hyperpolarization and increased [Ca2+](i). Bradykinin (4 mu M) had no direct effect on membrane potential or [Ca2+](i) on its own, but potentiated the subsequent ACh response. It changed the usual transient ACh response to a maintained hyperpolarization. The maintained hyperpolarization was blocked by NiCl2 and TEA, indicating an involvement of receptor-operated-Ca2+ channel and Ca2+-dependent K+-channel activity. This potentiating effect of bradykinin in isolated cells was confirmed in organ bath studies using isolated aortic rings. (C) 1995 Academic Press, Inc.

引用

下载

页码：1061 / 1067

页数：7

共 50 条

[41] MODULATION OF THE BRADYKININ-STIMULATED RELEASE OF PROSTACYCLIN FROM ENDOTHELIAL-CELLS
KEEN, M
PICKERING, SAW
HUNT, JA
BRITISH JOURNAL OF PHARMACOLOGY, 1990, 101 : P524 - P524
[42] The EDHF-dependent but not the NO-dependent component of the acetylcholine-induced relaxation of the rabbit aorta is resistant to ionized radiation
Soloviev, AI
Tishkin, SM
Parshikov, AV
Mosse, IV
Stefanov, AV
Osipenko, ON
Gurney, AM
EDHF 2000, 2001, : 400 - 409
[43] BRADYKININ INDUCES SUPEROXIDE ANION RELEASE FROM HUMAN ENDOTHELIAL-CELLS
HOLLAND, JA
PRITCHARD, KA
PAPPOLLA, MA
WOLIN, MS
ROGERS, NJ
STEMERMAN, MB
JOURNAL OF CELLULAR PHYSIOLOGY, 1990, 143 (01) : 21 - 25
[44] ISOLATION AND CHARACTERIZATION OF VASOFORMATIVE ENDOTHELIAL-CELLS FROM THE RAT AORTA
NICOSIA, RF
VILLASCHI, S
SMITH, M
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 1994, 30A (06) : 394 - 399
[45] BRADYKININ-INDUCED POTASSIUM CURRENT IN CULTURED BOVINE AORTIC ENDOTHELIAL-CELLS
COLDENSTANFIELD, M
SCHILLING, WP
POSSANI, LD
KUNZE, DL
JOURNAL OF MEMBRANE BIOLOGY, 1990, 116 (03): : 227 - 238
[46] Reticulocyte 15-lipoxygenase-I is important in acetylcholine-induced endothelium-dependent vasorelaxation in rabbit aorta
Tang, X
Holmes, BB
Nithipatikom, K
Hillard, CJ
Kuhn, H
Campbell, WB
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (01) : 78 - 84
[47] PHARMACOLOGICAL ANALYSIS OF MUSCARINIC RECEPTORS ON THE SMOOTH-MUSCLE AND ENDOTHELIAL-CELLS OF THE RABBIT AORTA
HASHIMOTO, S
YAMANAKA, K
KIGOSHI, S
MURAMATSU, I
JAPANESE JOURNAL OF PHARMACOLOGY, 1985, 39 : P320 - P320
[48] CULTURED DOG AORTA ENDOTHELIAL-CELLS RELEASE A VASODILATORY PRODUCT(S) IN RESPONSE TO ACETYLCHOLINE AND ADENOSINE
WOODLEY, N
BARCLAY, JK
FASEB JOURNAL, 1995, 9 (03): : A32 - A32
[49] INVOLVEMENT OF ENDOTHELIAL-CELLS IN RELAXATION AND CONTRACTION RESPONSES OF THE AORTA TO ISOPROTERENOL IN NAIVE AND STREPTOZOTOCIN-INDUCED DIABETIC RATS
KAMATA, K
MIYATA, N
KASUYA, Y
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1989, 249 (03): : 890 - 894
[50] SOME PROPERTIES OF ENDOTHELIUM-DERIVED RELAXING FACTOR (EDRF) RELEASED FROM ENDOTHELIAL-CELLS OF RABBIT AORTA
FURCHGOTT, RF
KHAN, MT
FEDERATION PROCEEDINGS, 1986, 45 (03) : 425 - 425

← 1 2 3 4 5 →