HETEROCYCLIC ANNULATED STEROIDS FROM 2-HYDROXYMETHYLENE CANRENONE

被引：1

作者：

GORLITZER, K ^{[1
]}

MOORMANN, P ^{[1
]}

POLLOW, K ^{[1
]}

SCHAFFRATH, M ^{[1
]}

机构：

[1] UNIV MAINZ,EXPTL ENDOKRINOL ABT,GEBURTSHILFE & FRAUENKRANKHEITEN KLIN & POLIKLIN,D-55131 MAINZ,GERMANY

来源：

ARCHIV DER PHARMAZIE | 1995年 / 328卷 / 02期

关键词：

D O I：

10.1002/ardp.19953280212

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A-ring annulated heterocycles, the isoxazole 6, the pyrazoles 8 and the pyrimidines 9 are prepared starting from 2-hydroxymethylene canrenone 1. Binding studies were carried out with the compounds 1 and 6-8 using estrogen, progesterone, androgen, gluco- and mineralocorticoid receptors as well as the serum proteins SHBG and CBG: the substances were inactive on the receptor level. 1, 7 and 8a show weak binding affinity to CBG.

引用

页码：157 / 160

页数：4

共 50 条

[31] D-Ring modification of steroids: synthesis of isoxazole annulated steroids from des D-formyl alkyne via 1,3-dipolar cycloaddition reaction
Nongthombam, Geetmani Singh
Boruah, Romesh Chandra
SYNTHETIC COMMUNICATIONS, 2021, 51 (18) : 2853 - 2861
[32] AMINO-DERIVATIVES AND DIENAMINO-DERIVATIVES FORMED FROM ADRENOCORTICAL STEROIDS AND HETEROCYCLIC BASES
RAPI, G
MARTINELLI, M
GINANNESCHI, M
CHELLI, M
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1972, (04): : 502 - +
[33] HETEROCYCLIC STEROIDS .3. MASS SPECTRA OF 6-AZASTEROIDS WITH 2 AROMATIC RINGS
PANDIT, UK
SPECKAMP, WN
HUISMAN, HO
TETRAHEDRON, 1965, 21 (07) : 1767 - &
[34] HETEROCYCLIC STEROIDS .20. 2+4 CYCLOADDITION OF N-CHLOROSULFONYLISOCYANATE TO A VINYLDIHYDRONAPHTHALENE
BARENDS, RJP
SPECKAMP, WN
HUISMAN, HO
TETRAHEDRON LETTERS, 1970, (60) : 5301 - &
[35] HETEROCYCLIC STEROIDS .2. PREPARATION AND N.M.R. SPECTRA OF 17,17-DIALKYL-13(14)-UNSATURATED STEROIDS
CASPI, E
PIATAK, DM
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1963, 41 (09): : 2294 - &
[36] CYCLIC KETALS FROM 2-HYDROXYMETHYLENE-HEXACHLORO-NORBORN-5-ENES BY ALKALINE DECHLORINATION
PERSCHEID, M
BALLSCHM.K
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 1973, B 28 (7-8): : 549 - 550
[37] Zn(L-proline)2 as an efficient and reusable catalyst for the multi-component synthesis of pyran-annulated heterocyclic compounds
Tahmassebi, Daryoush
Blevins, John E.
Gerardot, Shori S.
APPLIED ORGANOMETALLIC CHEMISTRY, 2019, 33 (04)
[38] STEROIDS FROM HYDRODEOXYCHOLIC ACID .2.
EBERHARDT, U
PHARMAZIE, 1975, 30 (05): : 280 - 282
[39] 2 STEROIDS FROM CALVATIA-CYATHIFORMIS
KAWAHARA, N
SEKITA, S
SATAKE, M
PHYTOCHEMISTRY, 1995, 38 (04) : 947 - 950
[40] CAMPHOR DERIVATIVES .2. CHELATE COPPER COMPOUNDS FROM SOME AMINO ANALOGS OF (-)-(HYDROXYMETHYLENE)CAMPHOR
TERENTEV, AP
PANOVA, GV
JOURNAL OF GENERAL CHEMISTRY USSR, 1970, 40 (06): : 1389 - &

← 1 2 3 4 5 →