HETEROCYCLIC ANNULATED STEROIDS FROM 2-HYDROXYMETHYLENE CANRENONE

被引：1
|
作者：
GORLITZER, K [1 ]
MOORMANN, P [1 ]
POLLOW, K [1 ]
SCHAFFRATH, M [1 ]
机构：
[1] UNIV MAINZ,EXPTL ENDOKRINOL ABT,GEBURTSHILFE & FRAUENKRANKHEITEN KLIN & POLIKLIN,D-55131 MAINZ,GERMANY
来源：
ARCHIV DER PHARMAZIE | 1995年 / 328卷 / 02期
关键词：
D O I：
10.1002/ardp.19953280212
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A-ring annulated heterocycles, the isoxazole 6, the pyrazoles 8 and the pyrimidines 9 are prepared starting from 2-hydroxymethylene canrenone 1. Binding studies were carried out with the compounds 1 and 6-8 using estrogen, progesterone, androgen, gluco- and mineralocorticoid receptors as well as the serum proteins SHBG and CBG: the substances were inactive on the receptor level. 1, 7 and 8a show weak binding affinity to CBG.
引用
收藏
页码：157 / 160
页数：4
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