HETEROCYCLIC ANNULATED STEROIDS FROM 2-HYDROXYMETHYLENE CANRENONE

被引：1

作者：

GORLITZER, K ^{[1
]}

MOORMANN, P ^{[1
]}

POLLOW, K ^{[1
]}

SCHAFFRATH, M ^{[1
]}

机构：

[1] UNIV MAINZ,EXPTL ENDOKRINOL ABT,GEBURTSHILFE & FRAUENKRANKHEITEN KLIN & POLIKLIN,D-55131 MAINZ,GERMANY

来源：

ARCHIV DER PHARMAZIE | 1995年 / 328卷 / 02期

关键词：

D O I：

10.1002/ardp.19953280212

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A-ring annulated heterocycles, the isoxazole 6, the pyrazoles 8 and the pyrimidines 9 are prepared starting from 2-hydroxymethylene canrenone 1. Binding studies were carried out with the compounds 1 and 6-8 using estrogen, progesterone, androgen, gluco- and mineralocorticoid receptors as well as the serum proteins SHBG and CBG: the substances were inactive on the receptor level. 1, 7 and 8a show weak binding affinity to CBG.

引用

页码：157 / 160

页数：4

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