HPLC DETERMINATION OF COPPER(II), COBALT(II) AND IRON(II) IN PHARMACEUTICAL PREPARATIONS USING 2-ACETYLPYRIDINE-4-PHENYL-3-THIOSEMICARBAZONE DERIVATIZING AGENT

被引：0
|
作者：
KHUHAWAR, MY
MEMON, ZP
LANJWANI, SN
机构：
来源：
CHROMATOGRAPHIA | 1995年 / 41卷 / 3-4期
关键词：
COLUMN LIQUID CHROMATOGRAPH; CU(II); CO(II); FE(II) IN PHARMACEUTICALS; PHENYL THIOSEMICARBAZONE DERIVATIVES;
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Cu(II) Co(II) and Fe(II) in pharmaceutical preparations were determined using precolumn derivatization and solvent extraction with 2-acetylpyridine-4-phenyl-3-thiosemicarbazone (APPT) as complexing reagent. Liquid chromatography (LC) was carried out on a reversed phase C-18, column. The complexes were eluted isocratically with acetonitrile-water containing sodium acetate and tetrabutyl ammonium bromide as ion-pairing agents. The results obtained were compared with those using atomic absorption.
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页码：236 / 237
页数：2
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